Plant-based compounds as Radionuclide Decorporation Agents AND Mechanisms Involved in Radiation Sensitivity

本次IAA将由2个项目组成。 项目1将研究植物性化合物(如染料木素、栎素和姜黄素，以及香菇中提取的一种β-葡聚糖化合物)是否可以用作无毒的辐射装饰剂。 项目2将研究两个对辐射敏感性不同的小型猪品系(哥廷根和辛克莱MP)中IGF-1/Akt/eNOS途径的活性与生存之间的正相关关系，并将该发现推广到不同的物种(小鼠)。

This IAA will be composed of 2 projects. Project 1 will examine if plant-based compounds (such as genistein, quercetin, and curcumin, as well as lentinan, a β-glucan compound derived from shiitake mushrooms), can be used as non-toxic radiation decorporation agents. Project 2 will examine the positive association between activity of the IGF-1/Akt/eNOS pathway and survival in two minipig strains (Gottingen and Sinclair MP) with different sensitivity to irradiation, and extend the generalizability of the finding to a different species (mice).