Using Text Messaging to Increase HPV Vaccination among Young Sexual Minority Men

项目摘要/摘要 人乳头瘤病毒(HPV)是一种常见的性传播感染，可导致肛门、阴茎、 男性口咽癌。由于他们的性行为，男男性行为者(MSM)在 HPV感染的风险特别高，并且受HPV相关癌症的影响不成比例。一个保险箱和 有有效的疫苗可以预防HPV感染，但美国的HPV疫苗接种率一直很低， 尤其是在男性中。免疫实践咨询委员会(ACIP)建议HPV 为所有MSM接种疫苗，直至26岁。然而，最近对全国同性恋和艾滋病样本的研究 18-26岁的双性恋男性表示，只有13-21%的人已经开始接种三剂HPV疫苗系列。我们的飞行员 研究表明，许多男男性同性恋者根本没有意识到疫苗或感知到其他重要的障碍 接种疫苗。为了弥补这一差距，拟议的研究的目标是开发和试点测试文本 信息干预以增加年轻男男性接触者的HPV疫苗接种。拟议的干预措施结合了 以证据为基础的方法，通过短信增加疫苗接种(“提醒-召回”)。除了……之外 通过提供基础教育和行动提示，短信可以量身定制，以解决特定的障碍。这个 这项研究的长期目标是制定有效的战略，增加MSM中HPV疫苗的接种， 从而降低与HPV相关癌症的发病率、死亡率和差异。对PA的回应- 15-263(性和性别少数群体的健康)，本R21申请的目标是 开发和试点短信干预措施，以增加年轻成年MSM的HPV疫苗接种。引导式 根据信息、动机和行为技能(IMB)模型，我们提出了两个具体目标：(1) 使用5步形成性研究程序开发、迭代提炼和预测试消息。目标用户 (即，18-26岁的男同性恋者、双性恋者或酷儿)将被招募来协助 这一过程。(2)测试Txt4预防(T4P)文本的可行性、可接受性和初步效果 一项试点随机对照试验(RCT)中的消息传递干预。参与者将被随机分配到 治疗(T4P)或对照条件。治疗条件将接受文化上合适的HPV 基于IMB模式的疫苗接种干预，而对照条件将接受一般的性行为 健康干预，包括有关HPV疫苗接种的基本事实，可在网上随时获得。主要结果 衡量标准包括干预可行性(招聘和保留)、可接受性(对 干预)，以及初步疗效由开始和完成3剂量系列在 为期9个月的试验结束。疫苗接种状态将通过参与者的医疗记录和伊利诺伊州 免疫接种登记处。这些目标的成果预计将在#年产生重要的积极影响。 确定在性少数男性中增加HPV疫苗接种的有效策略。

Project Summary/Abstract Human papillomavirus (HPV) is a common sexually transmitted infection that causes anal, penile, oropharyngeal cancers in men. Due to their sexual practices, men who have sex with men (MSM) are at particularly high risk for HPV infection and are disproportionately affected by HPV-related cancers. A safe and effective vaccine is available to prevent HPV infection, yet HPV vaccination rates in the U.S. have been low, particularly among males. The Advisory Committee on Immunization Practices (ACIP) recommends HPV vaccination for all MSM through age 26. Nevertheless, recent studies with national samples of gay and bisexual men aged 18-26 indicate that only 13-21% have initiated the 3-dose HPV vaccine series. Our pilot work suggests that many MSM are simply unaware of the vaccine or perceive other important barriers to getting vaccinated. To remedy this gap, the goal of the proposed research is to develop and pilot test a text messaging intervention to increase HPV vaccination in young MSM. The proposed intervention combines an evidence-based approach to increasing vaccination (“reminder-recall”) with text messaging. In addition to providing basic education and a cue to action, text messages can be tailored to address specific barriers. The long-term goal of this research is to develop effective strategies for increasing HPV vaccination among MSM, thereby reducing morbidity, mortality, and disparities associated with HPV-related cancers. In response to PA- 15-263 (The Health of Sexual and Gender Minority Populations), the objective of this R21 application is to develop and pilot test a text messaging intervention to increase HPV vaccination in young adult MSM. Guided by the Information, Motivation, and Behavioral Skills (IMB) Model, we propose to two specific aims: (1) Develop, iteratively refine, and pre-test messages using a 5-step formative research procedure. Intended users of the program (i.e., men who identify as gay, bisexual, or queer 18-26 years old) will be recruited to assist with this process. (2) Test the feasibility, acceptability, and preliminary efficacy of the Txt4Prevention (T4P) text messaging intervention in a pilot randomized controlled trial (RCT). Participants will be randomized to the treatment (T4P) or control condition. The treatment condition will receive a culturally appropriate HPV vaccination intervention based on the IMB model, whereas the control condition will receive a general sexual health intervention that includes basic facts about HPV vaccination readily accessible online. Primary outcome measures include intervention feasibility (recruitment and retention), acceptability (satisfaction with the intervention), and preliminary efficacy as determined by initiation and completion of the 3-dose series at the end of the 9-month trial. Vaccination status will be verified by participants' medical records and the Illinois Immunization Registry. Outcomes from these aims are expected to have an important positive impact by identifying effective strategies for increasing HPV vaccination among sexual minority men.