Advanced Research Training in Transplantation Science

摘要 这一竞争性续延旨在为11-15年的成功机构培训赠款提供资金，重点是 器官和组织移植的科学。移植科学高级研究培训 埃默里大学（Emory University）的ARTTS计划服务于医学科学，移植生物学领域，即 非常严格，独特的多学科，迫切需要新的学生来承担大量的 这是过去20年来形成的势头。该申请旨在资助1名前博士和2名博士后 学员每年一名，个别委任为期两年。它旨在培养受训人员， 在移植生物学领域建立独立的研究计划。自2006年成立以来， 项目已成功招收和培养了6名博士预科生和9名博士后。的6 博士前ARTTS学员谁已经完成培训，100%有第一作者出版物的结果， 他们的研究生研究，第一作者和总出版物的平均数量为2.67 （范围1-4）和5.17（范围1-9）。在过去的6名博士后ARTTS学员中， 完成培训，100%的博士后研究结果是第一作者出版物， 该组的第一作者和总出版物的平均数量分别为1.9（范围1-6）和4.3（范围2-8）， 分别此外，93.3%的ARTTS计划学员从事研究密集型职业或仍在从事研究密集型职业。 训练因此，该计划在招募和培训下一代方面非常成功。 移植科学家目前的提案代表了一个高度专业化的团队的持续承诺， 富有成效的，多样化的，积极合作的初级和高级研究员/导师，与相关的小组 专门的教师，在一个强大的机构基础上的基本学术卓越，执行一个 独特和精心设计的培训计划，将继续吸引和留住积极性高的学员 移植领域，并给予他们独特的工具集，需要影响的普遍问题， 领域在当前的应用中，我们提出进一步增强基本的， 通过提供临床和转化科学方面的正规培训， 分析学、生物信息学和临床试验设计。因此，ARTTS计划现在提供了令人难以置信的丰富内容 在移植和病毒免疫学中，环境跨越强大的小鼠模型， 翻译计划在耶基斯国家灵长类动物中心，并显着增加的机会，在临床 临床试验和人体免疫学该计划继续发展，以更好地吸引高素质的候选人 来自全国各地代表了种族和民族的多样性，重要的是现在提供了一项研究， 重点关注少数群体在移植方面的健康差异。因此，目前的产品是在切割 移植科学培训的边缘，无疑将有助于改善移植科学的未来 移植研究和实践，并优化移植受体的寿命和生活质量。

Abstract This competitive renewal seeks funding for years 11-15 of a successful institutional training grant focusing on the science of organ and tissue transplantation. The Advanced Research Training in Transplantation Sciences (ARTTS) program at Emory University serves an area of medical science, transplantation biology, that is exceptionally rigorous, uniquely multidisciplinary, and in dire need of new students to take up the substantial momentum established in the past 20 years. The application seeks to fund 1 pre-doctoral and 2 post-doctoral trainees each year, and individual appointments will last for 2 years. It seeks to produce trainees that go on to establish independent research programs in the area of transplantation biology. Since its inception in 2006, the program has successfully recruited and trained 6 pre-doctoral trainees and 9 post-doctoral trainees. Of the 6 pre-doctoral ARTTS trainees who have completed training, 100% had a first author publication as a result of their graduate research, and the average numbers of first author and total publications for this group was 2.67 (range 1-4) and 5.17 (range 1-9), respectively. Of the 6 past post-doctoral ARTTS trainees who have completed training, 100% had a first author publication as a result of their post-doctoral research, and the average numbers of first author and total publications for this group was 1.9 (range 1-6) and 4.3 (range 2-8), respectively. Furthermore, 93.3% of ARTTS Program trainees are in research-intensive careers or are still in training. Thus, the program has been highly successful in recruiting and training the next generation of transplantation scientists. The current proposal represents the continued commitment of a team of highly productive, diverse, and actively collaborating junior and senior investigator/mentors, with an associated group of dedicated instructors, on a strong institutional foundation of fundamental academic excellence, to execute a unique and carefully designed training program that will continue to attract and retain highly motivated trainees to the transplantation field, and give them the unique tool set needed to influence the prevailing problems in the field. In the current application we propose to further enhance communication and collaboration between basic, translational, and clinical transplantation sciences by offering formal training in clinical and translational science analytics, bioinformatics, and clinical trial design. The ARTTS Program thus now offers an incredibly rich environment spanning powerful murine models in transplantation and viral immunology, an intensive translational program at the Yerkes National Primate Center, and markedly augmented opportunities in clinical trials and human immunology. The program continues to evolve to better attract highly qualified candidates from across the country representing a diversity of races and ethnicities, and importantly now offers a research focus on health disparities among minority groups in transplantation. Thus, the current offering is on the cutting edge of training in transplantation sciences, and undoubtedly will contribute to improving the future of transplantation research and practice, and optimizing both length and quality of life for transplant recipients.