Bioinformatics Core

核心摘要 生物信息学核心将作为数据交换中心，提供标准化的质量 保证，序列数据处理和可视化的所有四个项目的这一赠款。通过 这样做将确保兼容和一致的数据格式，参数优化， 集中存储。现有的UMMS生物信息学管道将被优化， 提供并标准化读段比对、比对处理（峰识别、转录 组装、小RNA作图等，富集分析（基因本体富集， 等等），和数据集整合（例如，不同基因组中piRNA的差异表达）。 条件）。因此，项目数据的集中储存、处理和分析将 大大加强了项目所有四个组成部分之间的一体化。 相关性 生物信息学核心（核心C）提供的服务对研究至关重要 这四个项目都提出了。核心将提供存储，质量控制， 来自三个实验项目（I-III）的高通量数据的初步分析， 并将这些数据提供给计算项目进行深入研究（项目IV）。

Core Summary The bioinformatics core will serve as a data clearinghouse, offering standardized quality assurance, sequence data handling and visualization to all four projects of this grant. By doing so it will ensure compatible and consistent data formats, parameter optimization and centralized storage. Existing UMMS bioinformatics pipelines will be optimized to provide and standardize read alignment, alignment processing (peak calling, transcript assembly, small RNA mapping, etc., enrichment analysis (Gene Ontology enrichments, etc.), and dataset integration (e.g. differential expression of piRNAs in different conditions). The centralized storage, processing and analysis of project data will thus significantly enhance integration between all four project components. Relevance The services provided by the Bioinformatics Core (Core C) are essential to research proposed by all four Projects. The core will provide storage, quality control, and preliminary analysis of high-throughput data from the three experimental projects (I-III), and make this data available to the computational project for in depth study (Project IV).