RESOURCE/SERVICE CORE C - MOLECULAR INFORMATICS MODULE

摘要 分子信息学模块 分子信息学模块将提供蛋白质组和基因组研究 向参与P30核心资助的研究人员提供战略和技术 视觉研究。发展蛋白质组和基因组学专业知识所需的时间 技术经常给有能力的调查人员带来研究障碍 专业技能。具体来说，该模块将提供实验设计咨询， 为正常的全球和靶向蛋白质定量提供技术支持和数据分析 和患病的眼组织/细胞系统；为蛋白质组学提供集中的资源 涉及蛋白质的视觉科学研究的研究策略和技术支持 鉴定、蛋白质-蛋白质相互作用和翻译后修饰；提供 正常和正常的基因图谱的实验设计咨询和技术支持 疾病的眼组织和细胞系统；并提供集中资源 视觉科学研究需要的基因组研究战略和技术支持 基因分型、基因突变/多态分析和多标签平板阅读器 分析(细胞分析、免疫分析、动力学和结合分析、药物筛选)。 访问此核心模块将支持NEI R01资助的调查人员，帮助新的 招聘调查人员为NEI R01拨款申请获取数据，促进协作 RO1资助的调查员和新招募的调查员之间的互动，吸引 来自其他部门的调查人员对视觉系统的研究和研究具有重要意义 在我们的项目中吸引更多视觉科学家的部门资源，因为我们 扩充我们的研究人员队伍。

Abstract Molecular Informatics Module The Molecular Informatics Module will provide proteomic and genomic research strategies and technologies to the investigators involved in this P30 Core Grant for Vision Research. The time required to develop expertise in proteomic and genomic technologies often generates research roadblocks to capable investigators with other specialized skills. Specifically the module will provide experimental design consultation, technical support and data analysis for global and targeted protein quantitation in normal and diseased ocular tissues/cell systems; provide a centralized resource for proteomic research strategy and technical support for vision science studies involving protein identification, protein-protein interactions and posttranslational modifications; provide experimental design consultation and technical support for gene profiling in normal and diseased ocular tissues and cell systems; and provide a centralized resource for genomic research strategy and technical support for vision science studies requiring genotyping, genetic mutation/polymorphism analyses, and multi-label plate reader assays (cellular assays, immunoassays, kinetic and binding assays, drug screens). Access to this core module will support NEI R01 funded investigators, help newly recruited investigators obtain data for NEI R01 grant submissions, foster collaborative interactions between RO1 funded investigators and newly recruited investigators, attract investigators from other departments to research on the visual system and be a valuable departmental resource in attracting additional vision scientists to our program as we expand our research faculty.