Lipid metabolism in the hypothalamus: implications for obesity and diabetes development

肥胖的定义是脂肪过度储存和脂肪代谢缺陷，不仅在脂肪组织中，而且在整个身体的大多数组织中也是如此。肥胖导致的脂代谢变化延伸到大脑，并与认知功能受损有关。这项工作旨在确定肥胖如何影响大脑关键摄食中心的神经元，以及神经元中过度的脂肪储存是否会导致体重调节和新陈代谢的变化。

Obesity is defined by excessive fat storage and defective lipid metabolism, not only in adipose tissue, but also in most tissues throughout the body. Obesity-induced changes in lipid metabolism extends to the brain and is associated with impaired cognitive function. This work aims to determine how obesity affects neurons in the key feeding centres of the brain, and whether excessive lipid storage in neurons induces changes in body weight regulation and metabolism.