Animal Research Infrastructure Improvements

摘要 为了更好地支持我们老龄化饲养场的需求，位于纽约的突变小鼠资源和研究中心 加州大学戴维斯分校（MMRRC-UCD）致力于改善我们内部的基础设施和设备。 M3高级防鼠屏障设施。作为突变小鼠模型的主要分销商，我们的基础设施 屏障是影响我们生产和分销的动物健康和福祉的关键因素 目前服务于41个国家。MMRRC-UCD是四个NIH资助的最大中心 财团，专门从事冷冻保存和有价值的突变小鼠模型的分布。在 继续努力，以提高我们的业务效率，我们已经分析了阻碍我们的不足之处， 优化生产，并确定了一个关键因素是老化和过时的设备。老年动物饲养和 程序设备可能导致能源和水的使用增加，除了过度的噪音和 与更先进的现代化技术相比，振动会增加动物的压力。 因此，动物生产可能受到损害，运营成本增加。实验室 动物社区一直大力提倡“3R”，即替代，减少和 精炼。然而，我们现在所处的时代，我们也必须倡导我们所设想的"5E"： 有效性，排除，人机工程学，丰富和教育。我们的目标是改善基础设施 我们的屏障设施，通过实施精益管理原则，强调环境资源 使用我们创新的5E方法。目前的提案要求资金升级过时的动物转移 在M3屏障设施的生物安全站和生物安全柜中。此外，我们将停止使用水 瓶作为动物的水源，并转换为使用Hydropac ™袋提供无菌水 减少污染源，从而降低病原体的风险，减少所使用的环境资源。MMRRC- UCD致力于有利地整合创新概念，以实现更高的效率，独特和符合人体工程学 动物园的设计，将我们的标准啮齿动物屏障设施转化为精益的最先进的原型， 绿色动物研究机构，引导其他机构，使我们的原则适用于全球。

Abstract To better support the needs of our aging vivarium, the Mutant Mouse Resource and Research Center at the University of California, Davis (MMRRC-UCD) is driven to improve the infrastructure and equipment within our M3 high-level rodent barrier facility. As a premier distributor of mutant mouse models, the infrastructure of our barrier is a critical factor influencing the health and well-being of the animals we produce and distribute worldwide, currently serving 41 countries. The MMRRC-UCD is the largest center of the four NIH-funded consortiums, and specializes in the cryopreservation and distribution of valuable mutant mouse models. In continued efforts to improve the efficiencies of our operations we have analyzed the deficiencies hindering our optimal production and identified a key factor being aged and outdated equipment. Older animal housing and procedure equipment can lead to increased energy and water use, in addition to excessive noise and vibrations compared to more advanced modernized technologies, all leading to increase stress to the animal. As a result, animal production may be compromised and the costs of operations increased. The laboratory animal community has been strong advocates to promote the “3R’s” being Replacement, Reduction and Refinement. However, we are now in an era when we must also advocate for what we envision as the “5E’s”: Efficiencies, Exclusion, Ergonomics, Enrichment, and Education. Our goal is to improve the infrastructure at our barrier facility by implementing lean management principles with an environmentally resourceful emphasis using our innovative 5E’s approach. The current proposal requests funds to upgrade outdated animal transfer stations and biosafety cabinet in the M3 Barrier Facility. Additionally, we will discontinue the use of water bottles as a water source for the animals and convert to using HydropacTM pouches to provide a sterile water source, thus reducing the risk of pathogens and decreasing the environmental resources used. The MMRRC- UCD strives to advantageously integrate innovative concepts for higher efficient, exclusive and ergonomic vivarium designs to transform our standard rodent barrier facility into a state of the art prototype of a Lean- Green animal research facility, to guild other institutions to enable our principles to be applied globally.