Elucidating the role of cognitive and physiological aspects of affect in alcohol use relapse

R&R7。项目摘要/摘要 迫切需要更好地了解导致复发的特定因素 酒精使用障碍(AUD)的治疗，以改进现有的治疗方法并开发新的干预措施 对这种无处不在且代价高昂的疾病。而心理和情感因素则被调查为 复发的预测因素，目前对复发风险的生理标记物知之甚少，大多数存在 研究还没有利用更新的实时心理评估方法。这项调查是 新颖之处在于它将同时研究与酒精复发相关的认知因素，如焦虑和 渴望，以及相关的自主神经系统过程，因为它们发生在环境中，以便 找出可能增加澳门氏症复发风险的心理和生理脆弱性。这项研究的目标是 确定预测复发的实时情感模式和情感不稳定模式，以及伴随而来 影响调节的生物标记物在意识之外工作，因此可能增加重要的， 目的了解情绪调节对AUD研究中自我报告措施的补充作用。 此外，该奖学金中概述的培训计划将为首席调查员提供一套重要的 这些技能将增强他在药物使用障碍领域进行尖端研究的能力 (肥胖症)和其他以情绪调节失调为特征的精神障碍。这将通过以下方式实现 生态瞬时评估(EMA)的专门培训--一种强大的研究模式 当个体与其环境交互时，实时的情感和行为过程。长期的 这项研究和随之而来的培训计划的目标是开发综合生物行为 酒精和其他肥皂水的治疗方法，解决个人的脆弱性，可能会破坏个人的 试图获得持久的缓解。这项研究将提供有关该实用程序和 应用EMA和动态心理生理评估等新评估技术的可行性 对成瘾障碍的研究，这有可能开辟新的研究途径。

R&R7. Project Summary/Abstract There is a pressing need to better understand specific factors that lead to relapse among individuals seeking treatment for alcohol use disorder (AUD) in order to improve existing treatments and develop new interventions for this pervasive and costly disorder. While psychological and affective factors have been investigated as predictors of relapse, little is currently known about physiological markers of relapse risk, and most existing research has not taken advantage of newer real-time psychological assessment methods. This investigation is novel in that it will study simultaneously, cognitive factors associated with alcohol relapse such as anxiety and craving, and associated autonomic nervous system processes as they occur in the environment, in order to identify psychological and biological vulnerabilities that may heighten relapse risk for AUD. The study's goal to identify patterns of real-time affect and patterns of affective lability that predict relapse, as well as attendant biomarkers of affect regulation that operate outside of conscious awareness, and thus may add important, objective information about affective regulation that can complement self-report measures in the study of AUD. Further, the training plan outlined in this fellowship will provide the principal investigator with an important set of skills that will grow his capacity to conduct cutting edge research in the areas of substance use disorders (SUDs) and other mental disorders characterized by affect dysregulation. This will be achieved through specialized training in ecological momentary assessment (EMA), a powerful research modality for studying affective and behavioral processes in real time, as individuals interact with their environment. The long-term goal of this program of research and the attendant training plan is to develop integrated biobehavioral treatments for alcohol and other SUDs that address individual vulnerabilities that can undermine individuals' attempts to achieve lasting remission. This study will provide valuable information about the utility and feasibility of applying novel assessment techniques like EMA and ambulatory psychophysiological assessment to the study of addictive disorders, which has the potential to open up new avenues of research.