Unified high performance analysis of imaging biomarkers for Alzheimer's disease
Unified high performance analysis of imaging biomarkers for Alzheimer's disease
批准号:
9108816
负责人:
Ronald Pierson
金额:
$60.0万
依托单位国家:
美国
项目类别:
财政年份:
2012
资助国家:
美国
项目状态:
已结题
起止时间:
2012-08-15 至 2017-06-30
关键词:
Adverse effectsAffectAlzheimer&aposs DiseaseAmyloidAreaAtrophicBiological MarkersBiological Neural NetworksBrainBrain imagingCerebrumCessation of lifeClinicClinicalClinical TrialsComplexComputer softwareDataData SetDatabasesDementiaDentate nucleusDiagnosisDiagnosticDiagnostic ImagingDisease ProgressionEnsureFailureGoalsHealthHippocampus (Brain)ImageImage AnalysisImpaired cognitionImpairmentIndividualInjuryInterventionLicensingLightLobeMagnetic Resonance ImagingMeasurementMeasuresMemoryMethodsModalityMonitorMonitoring Clinical TrialsMorphologic artifactsMorphologyMyelinNational Institute on AgingNeurodegenerative DisordersParietal LobePathologyPerformancePerfusionPharmaceutical PreparationsPhasePositron-Emission TomographyProcessProductionProtocols documentationQuality ControlReportingResearchResearch PersonnelSensitivity and SpecificitySpin LabelsStructureTemporal LobeTestingThickTimeValidationVascular DiseasesWhite Matter HyperintensityWorkbasebeta-site APP cleaving enzyme 1clinical applicationcognitive functiondesignfluorodeoxyglucose positron emission tomographyglucose metabolismhigh throughput analysishypoperfusionimaging biomarkerinterestmorphometrypotential biomarkerskillsstudy populationwhite matter
中文摘要
描述(由申请人提供):阿尔茨海默病是一种大脑神经退行性疾病,导致记忆和认知功能受损,最终导致死亡。阿尔茨海默病的病因和疾病进展机制尚不完全清楚,但大量的努力正在集中在研究和药物干预的问题上。脑图像分析有限责任公司开发了NeuroAnalytica,为阿尔茨海默病的生物标志物提供高质量的脑形态测量。该二期项目将扩大基本措施,包括广泛的模式和措施,研究表明,在阿尔茨海默病的潜在生物标志物是有用的。
英文摘要
DESCRIPTION (provided by applicant): Alzheimer's disease is a neurodegenerative disease of the brain causing impairments to memory and cognitive functions, eventually leading to death. The causes of Alzheimer's disease and mechanisms of disease progression are not fully understood, but an enormous amount of effort is being focused on the issues in research and pharmacologic interventions. Brain Image Analysis, LLC has developed NeuroAnalytica to provide high quality brain morphometry measures for biomarkers in Alzheimer's disease. This Phase II project will expand the basic measures to include a wide range of modalities and measures that research has shown to be useful in as potential biomarkers in Alzheimer's disease.
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会议论文
Optimizing automated MRI measures of atrophy in neurodegenerative disease
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批准号:8395094
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项目类别:
-
资助金额:$30.41万
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财政年份:2012
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负责人:Ronald Pierson
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依托单位:
Optimizing automated MRI measures of atrophy in neurodegenerative disease
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批准号:8525304
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项目类别:
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资助金额:$15.89万
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财政年份:2012
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负责人:Ronald Pierson
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依托单位:
Unified high performance analysis of imaging biomarkers for Alzheimer's disease
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批准号:8782370
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项目类别:
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资助金额:$60.0万
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财政年份:2012
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负责人:Ronald Pierson
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依托单位:
海外基金