Myanmar Regional Center of Excellence for Malaria Research

缅甸疟疾研究区域卓越中心（Myanmar Regional Center of Excellence for Malaria Research） 在NIAID于2009年宣布ICEMR计划之前不久， 在东南亚出现[1，2]，对全球疟疾控制和消灭构成严重威胁[3，4]。作为 非洲抗药性疟疾的出现和传播研究的领先中心[5-9]，我们的小组 应世界卫生组织（世卫组织）和区域合作伙伴的要求， 开展临床和基因组流行病学研究，以确定和验证青蒿素抗药性的分子标记 在亚洲[10-15]。部分基于我们对青蒿素出现和传播模式的发现， 由于该地区的耐药性[14]，2015年，世卫组织放弃了试图遏制青蒿素的战略 世界卫生大会批准了世卫组织的一项新建议，即发起一项运动， 在东南亚彻底消灭恶性疟疾[16]。沿着其他国家在2015年东 亚洲峰会，缅甸，新兴的民主国家，以前被称为缅甸，和东南亚国家 迄今为止疟疾负担最重的非洲国家[17]通过了到2030年在该区域消除疟疾的计划。 为了实现这一艰巨的目标，需要创新的疟疾监测、治疗和预防工具。 预防因为缅甸和邻国疟疾最严重的集中地是在 国家卫生系统往往无法覆盖的边境和冲突地区， 支持消灭疟疾的疟疾研究需要采取多部门、跨国界的办法。基础上 2012年，我们利用NIAID赠款在缅甸成功建立了一个疟疾研究项目， 在我们的支持下，并与本地和区域伙伴紧密合作，我们现建议成立一个新的综合环境管理研究中心 以缅甸为中心，在缅甸中部和与中国接壤的两侧都有遗址， 孟加拉国.整合临床和实地研究的结果，包括分子监测、基因组学、 流行病学和地理空间绘图和疟疾风险建模，我们将开展创新的多学科 为国家疟疾防治提供基本知识、工具和循证战略的研究 我们的合作伙伴致力于在东南亚控制、治疗并最终消除疟疾。

OVERVIEW Myanmar Regional Center of Excellence for Malaria Research Shortly before NIAID announced the ICEMR program in 2009, artemisinin-resistant falciparum malaria appeared in Southeast Asia [1,2], posing a serious threat to global malaria control and elimination [3,4]. As a leading center for research on the emergence and spread of drug resistant malaria in Africa [5-9], our group was asked by the World Health Organization (WHO) and regional partners to help design and lead a series of clinical and genomic epidemiology studies to identify and validate molecular markers for artemisinin resistance in Asia [10-15]. Based in part on our findings about the patterns of emergence and spread of artemisinin resistance in the region [14], in 2015 the WHO abandoned its strategy of trying to contain artemisinin resistance, and the World Health Assembly approved a new WHO recommendation to launch a campaign to completely eliminate falciparum malaria in Southeast Asia [16]. Along with other countries at the 2015 East Asia Summit, Myanmar, the emerging democracy formerly known as Burma, and the Southeast Asian country with by far the greatest malaria burden [17], endorsed a plan for malaria elimination in the region by 2030. To achieve this daunting goal, innovative tools are needed for malaria surveillance, treatment and prevention. Because the heaviest concentrations of malaria in Myanmar and neighboring countries are found in border and conflict areas that are often out of reach of national health systems, malaria elimination—and malaria research in support of elimination—requires a multi-sectoral, cross-border approach. Building on the foundation of a successful malaria research program that we created in Myanmar in 2012 with NIAID grant support, and working closely with local and regional partners, we now propose to establish a new ICEMR centered in Myanmar, with sites in central Myanmar and on both sides of its borders with China and Bangladesh. Integrating findings from clinical and field research, including molecular surveillance, genomic epidemiology and geospatial mapping and modeling of malaria risk, we will conduct innovative multidisciplinary research that will provide essential knowledge, tools, and evidence-based strategies for national malaria control programs and their partners to control, treat and ultimately eliminate malaria in Southeast Asia.