Central & Peripheral blood flow regulation in individuals with Down syndrome

项目摘要 工作能力是健康或身体功能下降以及死亡率的重要预测因素， 以峰值耗氧量来衡量。唐氏综合症患者的峰值耗氧量非常低， 智力残疾最普遍的遗传原因。先前的研究表明患有唐氏综合症的人 锻炼时可能会遇到双重缺点：他们可能无法增加心输出量 他们可能无法将足够的血流分配给工作的肌肉。其总体目标是 因此，研究建议确定血流的中枢和外周调节的限制的影响 对DS患者工作能力的影响我们的目标是检查急性和慢性运动反应，以更好地 了解潜在的机制和潜力，通过在干预措施中使用这些知识来改善健康。 候选人Thessa Hilgenkamp博士在个人健康的流行病学研究方面具有很强的背景 患有包括唐氏综合症在内的智力残疾的人。她的研究重点是身体活动的好处， 在这个人群中锻炼，她表现出巨大的潜力，成为一个成功的独立研究人员在这方面， 领域最近，她与博·芬霍尔博士一起在运动中测量自主调节方面取得了专业知识。 伊利诺伊大学芝加哥分校综合生理学实验室。她的长期目标是改善 唐氏综合征患者的健康在整个生命周期，通过充分了解自主神经功能障碍， 心血管调节对运动的反应，并在身体活动中实施这些知识， 练习干预。她的短期职业目标首先是成为一名技术熟练、知识渊博的专家， 唐氏综合征患者的心血管运动生理学和自主神经功能，其次是 成为这一特定领域的高潜力研究人员，无论是从学术界的角度， 临床实践和唐氏综合症的支持网络在社区的角度。这个职业 发展奖将使她接受额外的培训，在技术知识和技能，将符合 与临床实践合作开展研究项目， 和唐氏综合症的支持网络，并发展必要的转移技能，成为一个 成功的独立研究人员，如撰写资助，实验室管理和指导。她的导师是波博士 世界著名的心血管运动生理学和唐氏综合症专家费恩霍尔说， 由运动学和营养学系的Tracy Baynard博士和Philip Clifford博士支持， 伊利诺伊大学芝加哥分校。该部门致力于Hilgenkamp博士的学术发展， 为她提供所需的所有设施，包括综合生理学实验室的设备， 她需要的。她还得到了家长网络和伊利诺伊州特奥会的支持来进行这项研究。

Project Summary Work capacity is an important predictor of declining health or physical function, and of mortality, and is commonly measured as peak oxygen consumption. Peak oxygen consumption is very low in individuals with Down syndrome, the most prevalent genetic cause of intellectual disability. Previous research suggests individuals with Down syndrome may experience a double disadvantage when they are exercising: they may not be able to increase cardiac output sufficiently and they may not be able to allocate adequate blood flow to the working muscles. The overall aim of this research proposal is therefore to determine the impact of limitations in central and peripheral regulation of blood flow on work capacity in individuals with DS. We aim to examine both acute and chronic exercise responses to better understand the underlying mechanisms and the potential to improve health by using this knowledge in interventions. The candidate, Dr. Thessa Hilgenkamp, has a strong background in epidemiological research on health in individuals with intellectual disabilities including Down syndrome. Her research focuses on the benefits of physical activity and exercise in this population, and she has shown great potential to become a successful independent researcher in this field. Recently she has developed expertise in measuring autonomic regulation during exercise with Dr. Bo Fernhall in the Integrative Physiology Laboratory of the University of Illinois at Chicago. Her long-term goal is to improve the health of individuals with Down syndrome across the life span, by fully understanding autonomic dysfunction and cardiovascular regulation of the response to exercise and implementing this knowledge in physical activity and exercise interventions. Her short-term career goals are first to become a skilled, knowledgeable expert on cardiovascular exercise physiology and autonomic function in individuals with Down syndrome, and second to become a high-potential researcher in this specific field, both from the perspective of academia and from the perspective of clinical practice and the Down syndrome support networks in the community. This Career Development Award will allow her to receive additional training in technical knowledge and skills that will be in line with and complementary to the research proposal, to conduct research projects in collaboration with clinical practice and the Down syndrome support networks in the community, and to develop transferable skills necessary to become a successful independent researcher, such as grant writing, lab management and mentoring. Her mentor is Dr. Bo Fernhall, a world-renowned expert on cardiovascular exercise physiology and Down syndrome, and she will also be supported by Dr. Tracy Baynard and Dr. Philip Clifford of the Department of Kinesiology and Nutrition of the University of Illinois at Chicago. This Department is committed to Dr. Hilgenkamp's academic development and provides her with all the facilities she needs, including the equipment in the Integrative Physiology Laboratory that she needs. She also has the support of parent networks and the Special Olympics Illinois to conduct this research.