Central & Peripheral blood flow regulation in individuals with Down syndrome

中央

• 批准号: 10254383
• 负责人: Thessa Hilgenkamp
• 金额: $ 24.38万
• 依托单位: UNIVERSITY OF NEVADA LAS VEGAS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10254383
• 关键词: Address; Attenuated; Autonomic Dysfunction; Autonomic nervous system; Birth; Blood; Blood Pressure; Blood flow; Cardiac; Cardiac Output; Cardiovascular system; Catecholamines; Chronic; Clinical; Data; Disadvantaged; Down Syndrome; Exercise; Genetic; Health; Heart Rate; Impairment; Individual; Intellectual functioning disability; Knowledge; Lower Body Negative Pressure; Measures; Mediating; Metabolic; Motivation; Muscle; Nature; Nutrient; Oxygen; Oxygen Consumption; Peripheral; Physical Function; Regulation; Research; Research Proposals; Risk; Shunt Device; Testing; Tissues; Vasodilation; Work; blood pressure regulation; clinical practice; design; disability; exercise intervention; exercise training; experience; improved; mortality; peripheral blood; physical inactivity; response; vasoconstriction

Down syndrome (DS) is the most prevalent genetic cause of intellectual disability and occurs in approximately 1 in every 700 births in the US. Individuals with DS are at increased risk for a number of health issues. Work capacity is an important predictor of declining health or physical function, and of mortality, and is commonly measured as peak oxygen consumption. Peak oxygen consumption is very low in individuals with DS, and cannot be explained by physical inactivity, lack of motivation, or lack of understanding of the test. To date, the nature of the limitations in work capacity in DS is unknown, and the proposed research aims to address this knowledge gap. Work capacity is determined by central and peripheral regulation of blood flow (i.e. cardiac output and maintaining arterial blood pressure vs. supplying exercising muscles with oxygen and nutrients). These factors are governed by the sympathetic and parasympathetic branches of the autonomic nervous system. Central regulation of blood flow is impaired in individuals with DS due to cardiovascular autonomic dysfunction, whereby parasympathetic activity is high and sympathetic control is reduced. This results in lower heart rate, less adequate blood pressure control and attenuated catecholamine levels during exercise. It is unknown to what extent this impaired central control impacts cardiac output, and subsequently work capacity, during exercise in individuals with DS. Peripheral blood flow regulation is even less studied in individuals with DS. Peripheral regulation involves sympathetically regulated vasoconstriction in non-active muscles and tissues, and local mechanisms regulating vasodilation in working muscles, which facilitates blood flow to working muscle in order to meet metabolic demand. Individuals with DS may partly experience reduced work capacity due to this inability to shunt blood to the working tissue effectively. The aim of this research proposal is therefore to determine the impact of limitations in central and peripheral regulation of blood flow on work capacity in individuals with DS. We aim to examine the responses to exercise training to better understand the underlying mechanisms and the potential to improve health by using this knowledge in exercise interventions.

唐氏综合征（DS）是智力残疾的最普遍的遗传原因， 在美国，每700个新生儿中就有一个。患有DS的个体在许多方面的风险增加， 健康问题。工作能力是健康或身体功能下降的重要预测因素， 死亡率，并且通常测量为峰值耗氧量。峰值耗氧量非常 DS患者的低，并且不能解释为缺乏身体活动，缺乏动力或缺乏 理解测试。到目前为止，DS工作能力限制的性质尚不清楚， 拟议的研究旨在弥补这一知识差距。 做功能力由血流的中枢和外周调节（即心输出量和 维持动脉血压与向运动肌肉供应氧气和营养物）。这些 这些因素是由自主神经的交感神经和副交感神经分支控制的 系统由于心血管疾病，DS患者的血流中枢调节受损 自主神经功能障碍，由此副交感神经活性高并且交感神经控制降低。这 导致心率降低、血压控制不足和儿茶酚胺水平降低 在运动中。尚不清楚这种受损的中枢控制在多大程度上影响心输出量， 随后的工作能力，在个人与DS运动。 外周血流量调节在DS患者中的研究更少。外围调节包括 交感神经调节非活动性肌肉和组织的血管收缩，以及局部机制 调节工作肌肉中的血管舒张，这有助于血液流向工作肌肉，以满足 代谢需求。患有DS的个人可能会部分地由于这种能力而降低工作能力 有效地将血液分流到工作组织。 因此，本研究提案的目的是确定中央和地方限制的影响， 外周血流量调节对DS患者做功能力的影响。我们的目的是研究 对运动训练的反应，以更好地了解潜在的机制和潜力， 通过在运动干预中使用这些知识来改善健康。