Mali ICEMR- Data Management and Biostatistics Core

核心B--摘要 在过去十年中，疟疾控制工具的广泛部署大大促进了 减少撒哈拉以南非洲与该疾病有关的发病率和死亡率。然而，该地区继续 疟疾死亡在全球疟疾负担中所占的比例高得不成比例。此外，发病率 在某些情况下保持高位但稳定，而在其他情况下在长期下跌后出现反弹 随着密集部署疟疾控制工具。ICEMR的总体目标是了解变量 当前疟疾控制干预措施在西非不同生态环境中的有效性 研究以了解寄生虫之间的相互作用(对药物治疗的反应、基因类型、配子体 生存)、人类(免疫反应和宿主遗传学)和媒介(生态、行为和对 杀虫剂)和调节当地环境和人类行为的影响。数据的目标是 管理和生物统计(DMB)的核心是提供数据管理和生物统计支持 为了提供可靠和高质量的研究数据和数据分析，国际经济、经济、社会和文化权利国际中心向马里的调查人员提供了技术援助。这个 DMB的具体目标是：1]建立一个符合所有标准的数据管理系统办公室 与ICEMR协作，支持机密性、报告、数据质量和数据安全 调查员，2]支持ICEMR调查员进行研究规划、进行研究和数据管理 活动包括：项目管理、数据收集、数据录入、研究质量保证、数据存储和 检索和更新标准作业程序，以及数据库管理和流程；3] 支持ICEMR研究人员的方案设计和开发，监测研究，以及两者 中期和最终数据分析；4]提供所需的临床研究和数据分析培训 调查人员和技术人员必须达到所有标准。核心B将设在国立卫生研究院-巴马科大学 马里卓越研究中心。

CORE B – SUMMARY Wide deployment of malaria control tools in the past decade has significantly contributed to substantial reduction of the incidence and deaths related to the disease in Sub-Sahara Africa. Yet, the region continues to carry a disproportionately high share of the global malaria burden of malaria deaths. Moreover, incidence remains high but stable in some settings while rebounding in others after a long period of decrease associated with intensive deployment of malaria control tools. The Overall goal of this ICEMR is to understand the variable effectiveness of current malaria control interventions in different ecological settings of West Africa through research to understand interactions between the parasite (response to drug treatment, genotypes, gametocyte survival), human (immune response and host genetics) and the vector (ecology, behaviors, and response to insecticides) and regulating influences of the local environment and human behavior. The goal of the Data Management and Biostatistics (DMB) Core is to provide data management and biostatistical support to the ICEMR investigators of Mali in order to produce reliable and high quality research data and data analysis. The specific aims of DMB are: 1]To set up a data management system office meeting all standards of confidentiality, reporting, data quality, and data security to support, in collaboration with the ICEMR investigators, 2] To support ICEMR investigators in study planning, study conduct and data management activities including: project management, data collection, data entry, study quality assurance, data storage, and retrieval, and updating standard operating procedures, and in database management and processes; 3] Support ICEMR investigators in protocol designing and development, in monitoring of studies, and in both interim and final data analyses; 4] To provide required training in clinical research and data analysis for investigators and technicians to meet all standards. The Core B will be based at the NIH-University of Bamako Center of Excellence in Research, Mali.