Enrichment Program

摘要(充实计划) 光学成像技术和数字图像分析的非凡发展开启了新的 在体外标本和活体动物中研究生理学和病理生理学的机会。 多光子显微镜、薄膜和定量3D细胞术等技术将我们的探测范围扩展到 包括高分辨率亚细胞细节和大规模定量体积分析。传播 这些技术及其在肾脏和泌尿外科研究中的应用具有潜在的提供重要的 用其他方法无法获得的新见解。因此，浓缩计划服务于 奥布莱恩中心和国内和国际肾脏和泌尿系疾病研究人员 将中心开发的技术和资源尽可能广泛地提供给 调查人员。核心的三项具体活动将实现这一目标：1)年内的教学讲习班 1、3和5召集肾脏和泌尿外科领域的研究人员与光学领域的主要权威机构一起 成像在一个论坛上获得高级光学显微镜方法的实践培训，以促进 对话和解决问题；2)访问演讲者计划，让成像领域的领导者与Center互动 调查人员和工作人员以及与当地研究基地的合作；以及3)开发综合网络资源 用于传播方法、教育材料和软件。核心意志的这些活动 补充和扩大组成该中心的其他核心的其他非正式外联活动。这个 因此，浓缩计划是该中心的一个重要组成部分，有助于为 肾脏和泌尿系统疾病的国内和国际调查人员团体。

Abstract (Enrichment Program) Extraordinary developments in optical imaging technologies and digital image analysis have opened new opportunities to study physiology and pathophysiology in ex vivo specimens as well as the live animal. Techniques such as multiphoton microscopy, FLIM and quantitative 3D cytometry extend our probing reach to encompass both high resolution subcellular details and large-scale quantitative volume analysis. Dissemination of these technologies and their application in renal and urologic research has the potential to provide important new insight that cannot be obtained using other approaches. Therefore, the Enrichment Program serves the O'Brien Center and the national and international community of researchers in renal and urologic diseases by making available the technologies and resources developed in the Center to the widest possible range of investigators. Three specific activities of the Core will accomplish this goal: 1) instructional workshops in years 1, 3 and 5 to bring investigators in the renal and urologic field together with the leading authorities in optical imaging to obtain hands-on training in advanced methods of optical microscopy in a forum that facilitates dialogue and problem solving; 2) a visiting speakers program to bring leaders in imaging to interact with Center investigators and staff and with the local research base; and 3) development of a comprehensive web resource for dissemination of methods, educational materials and software. These activities of the Core will complement and extend other informal outreach activities of the other cores comprising this Center. The Enrichment Program, therefore, is an essential component of the Center that facilitates its service to the national and international community of investigators in renal and urologic diseases.