Tau in the Eye and Brain

项目摘要/摘要 微管相关蛋白(Tau)的进行性积累是阿尔茨海默病的一个明显特征 (AD)和其他一些称为紧张症的疾病。我们实验室的最新研究，证实了 其他研究表明，tau寡聚体构成了具有明显毒性和病理意义的tau物种。 能够通过突触间传递在紧张症大脑中传播。然而，准确的调查 神经网络的复杂性阻碍了tau齐聚物的扩散。有效诊断的方法 AD和其他tauopathy在早期阶段，并监测其进展也缺乏。除了认知之外 异常，AD患者表现为视力异常。在这个应用程序中，我们将检验tau的假设 视网膜的病理可能预示与tau相关的大脑功能障碍，这使它成为一个很好的研究平台。 Tau寡聚体菌株的繁殖，检测和监测AD和其他tau相关的进展 疾病，并评估我们新开发的tau寡聚体特异性单抗的疗效 (TOAS)靶向不同的tau寡聚菌株。这项研究的结果将提供明确的途径 低聚物的传播和帮助开发新的方法来监测和治疗自发性疾病。

PROJECT SUMMARY/ABSTRACT Progressive accumulation of microtubule-associated protein (tau) is a defining feature of Alzheimer's disease (AD) and a number of other disorders termed tauopathies. Recent studies from our laboratories, confirmed by others, demonstrated that tau oligomers constitute distinctly toxic and pathologically significant tau species able to spread in tauopathy brain, likely through inter-synaptic transmission. However, precise investigation of tau oligomer spreading is hindered by the complexity of the neuronal network. Methods to effectively diagnose AD and other tauopathies at early stages and monitor their progress are also lacking. In addition to cognitive abnormalities, AD patients show visual anomalies. In this application, we will test the hypothesis that tau pathology in the retina may predict tau-related dysfunction in the brain, making it an excellent platform to study the propagation of tau oligomeric strains, detect and monitor the progression of AD and other tau-related disorders, and evaluate the efficacy of our newly developed tau oligomer-specific monoclonal antibodies (TOMAs) at targeting different tau oligomeric strains. Outcomes from this study will provide clear pathways of oligomer spreading and aid in the development of novel approaches to monitor and treat tauopathies.