UNC Center for Environmental Health and Susceptibility

描述(由申请人提供) 北卡罗来纳州环境健康和敏感性中心(UNC-CEHS)的主题是将关于环境健康威胁的跨学科研究转化为改善北卡罗来纳州的公共健康。该中心鼓励和促进基础研究人员、公共卫生科学家和临床医生之间的合作，以产生影响重大的发现，改善公共健康。战略愿景由行政核心执行，行政核心负责管理预算、监督设施核心、评价创新试点项目并为其提供资金、赞助研讨会和专题讨论会、支持发展事业、与中心成员沟通、编写报告和通讯、跟踪出版物和赠款提案。该中心有三个设施核心，以促进生物样品的获取、分子分析以及数据分析和实验设计。这些核心确保向环境疾病研究传播经过验证和创新的新技术。综合健康科学设施核心提供生物检疫处理方面的专门知识，并帮助鼓励利用临床和基于人群的研究开展新的合作。生物统计和生物信息学设施核心提供研究设计、数据分析、培训和方法开发方面的专业知识，特别是支持强大的“组学”技术的应用。分子分析设备核心为质谱学、DNA损伤及其反应的评估、翻译组织病理学以及完整的基因分型和基因组学技术提供专业知识和仪器。每个核心的设计都是为了提高北卡罗来纳大学-CEHS调查人员的工作效率。该中心支持三个翻译研究重点领域：环境癌症、心肺疾病和发育性疾病。北卡罗来纳州的暴露往往与多种结果相关，因此，对类似环境健康威胁的研究统一了中心调查人员，提供了联系，并确保了UNC-CEHS的整合。科学研究得益于由北卡罗来纳大学-CEHS社区外联和参与核心领导的多方向交流，该中心提供了一种向公共卫生专业人员、社区卫生工作者、易感人群、家庭和终身学习者传播研究发现的手段。科学和推广项目得到了一个竞争性的试点项目的支持，该项目优先考虑初级教师。UNC-CEHS还积极指导和培养初级和中级职业调查人员的领导力，以培训下一代环境健康研究人员。通过利益攸关方咨询委员会和外部咨询委员会，UNC-CEHS接受关于社区关切的意见和关于中心有效性的反馈。北卡罗来纳大学-CEHS为北卡罗来纳州，最终为美国东南部和全国提供创新和战略性的科学活动和社区参与。

DESCRIPTION (provided by applicant) The theme of the UNC Center for Environmental Health and Susceptibility (UNC-CEHS) is translating interdisciplinary research on environmental health threats to improve public health in North Carolina. The Center encourages and facilitates collaborations among basic researchers, public health scientists, and clinicians to generate high impact discoveries that improve public health. The strategic vision is implemented by the Administrative Core which manages budgets, oversees the Facility Cores, evaluates and funds innovative pilot projects, sponsors seminars and symposia, supports developing careers, communicates with Center membership, prepares reports and newsletters, and tracks publications and grant proposals. The Center has three Facility Cores that facilitate biospecimen acquisition, molecular analyses, and data analysis and experimental design. These cores ensure dissemination of proven and innovative new technologies to environmental disease research. The Integrated Health Sciences Facility Core provides expertise in biospecimen processing and helps encourage new collaborations using clinical and population-based studies. The Biostatistics and Bioinformatics Facility Core provides expertise in study design, data analysis, training and methodology development that especially supports the application of powerful "omics" technologies. The Molecular Analysis Facility Core provides expertise and instrumentation for mass spectrometry, assessment of DNA damage and its responses, translational histopathology and the full complement of genotyping and genomics technology. Each of the cores is designed to enhance productivity of UNC-CEHS investigators. Three Translational Research focus areas are supported by the Center: environmental cancer, cardiopulmonary disease, and developmental disease. North Carolina exposures often are associated with multiple outcomes, and thus research on similar environmental health threats unifies center investigators, provides connectivity, and ensures integration of UNC-CEHS. Scientific studies benefit from multi-directional communication, led by the UNC-CEHS Community Outreach and Engagement Core, which provides a means to disseminate research discoveries to public health professionals, community health workers, susceptible populations, families and lifelong learners. The science and outreach projects are supported by a competitive Pilot Projects program that prioritizes junior faculty. UNC-CEHS also actively mentors and cultivates leadership of junior and mid-level career investigators to train the next generation of environmental health researchers. Through the Stakeholder Advisory Board and External Advisory Board the UNC-CEHS receives input on community concerns and feedback on Center effectiveness. UNC-CEHS serves North Carolina, and ultimately the southeastern United States and the nation with innovative and strategic scientific activities and community engagement.