Wadsworth Center's Children's Health Exposure Assessment Resource (WC-CHEAR)

 描述(由申请人提供)：沃兹沃斯中心儿童健康暴露分析资源(WC-CHEAR)的总体目标是建立一个世界级的实验室设施，满足NIH资助的研究人员对环境污染物对儿童健康的影响进行研究的需要。WC-CHEAR将把纽约州卫生部在纽约州奥尔巴尼的公共卫生实验室和生物医学研究设施与纽约大学医学院、生物化学和分子药理学系的巨大资源、能力和专业知识结合在一起。沃兹沃斯和纽约大学的这一合作伙伴关系将为研究人员提供最先进的专业分析设施，以支持儿童的环境健康研究。沃兹沃斯中心完全通过CLIA-88认证，可以支持多项由美国国立卫生研究院资助的研究，在这些研究中，儿童的尿液和/或血清将使用基于质谱学的技术分析有机化学污染物，包括但不限于多氯联苯、多环芳烃、含氟化合物、溴化阻燃剂、有机磷杀虫剂、酚类内分泌干扰物和邻苯二甲酸盐。这些实验室还能够使用基于无机质谱学的最灵敏的方法，分析儿童接触有毒重金属的生物样本，包括但不限于铅、镉、汞和砷。这些实验室还能够分析儿童的血液、血清/血浆和尿液中可能受到环境暴露影响的内源性化合物，包括激素、维生素、蛋白质标志物、电解质和代谢物组(包括但不限于雌激素、雄激素、睾酮、甲状腺组、甘油三酯、胆固醇、维生素D和B12、叶酸、同型半胱氨酸和胰岛素)。Wadsworth提供了广泛的能力来分析非传统基质，如胎盘、脐带血、乳牙、干血斑、头发、指甲和唾液中的有机和无机污染物，以支持测量儿童在其环境中接触有毒化学物质的新方法。沃兹沃斯和纽约大学将分享研究非靶标化合物的能力和专业知识，这两所大学的广泛能力是相辅相成的。WC-CHEAR将受益于沃兹沃斯中心在临床检验医学领域的国际声誉和领导地位，以及作为环境检验医学、临床化学和毒理学方面能力测试(PT)计划的组织者。Wadsworth在这方面的经验和能力将为NIEHS儿童健康环境分析资源(CHEAR)网络提供定制的PT计划，以支持生物监测研究和网络的需求。沃兹沃斯开发的CHEAR PT计划将产生具有良好特性的基于基质的标准物质，其中包含与生物监测相关的关键浓度范围内的外源和内源分析物，并将在整个CHEAR实验室网络中共享。

 DESCRIPTION (provided by applicant): The overall objective of the Wadsworth Center's Children's Health Exposure Analysis Resource (WC-CHEAR) is to establish a world-class laboratory facility that will serve the needs of NIH-funded investigators conducting research studies into the effects of environmental contaminants on children's health. The WC-CHEAR will bring together the tremendous resources, capabilities and expertise of the NY State Department of Health's public health laboratory and biomedical research facilities in Albany, NY with those of the NYU School of Medicine, Department of Biochemistry and Molecular Pharmacology. Together, this partnership between Wadsworth and NYU will provide researchers with access to state-of-the-art, specialized analytical facilities to support children's environmental health studies. The Wadsworth Center's is fully accredited under CLIA-88, and can support multiple NIH-funded studies, where children's urine and/or serum will be analyzed for organic chemical contaminants including, but not limited to, polychlorinated biphenyls, polycyclic aromatic hydrocarbons, fluorinated compounds, brominated flame retardants, organophosphate insecticides, phenolic endocrine disrupting chemicals, and phthalates using techniques based on mass spectrometry. The laboratories are also able to analyze children's biospecimens for exposure to toxic heavy metals including, but not limited to, Pb, Cd, Hg, and As using the most sensitive methods available based on inorganic mass spectrometry. The laboratories are also able to analyze children's blood, serum/plasma, and urine for endogenous compounds including hormones, vitamins, protein markers, electrolytes and metabolite panels (including but not limited to estrogens, androgens, testosterone, thyroid panels, triglycerides, cholesterol, vitamin D and B12, folate, homocysteine and insulin) that may be affected by environmental exposures. Wadsworth provides extensive capabilities for analyzing non-traditional matrices such as placenta, cord blood, baby teeth, dried blood spots, hair, nails, and saliva for organic and inorganic contaminants to support novel approaches to measure children's exposure to toxic chemicals in their environment. Capability and expertise for investigating untargeted compounds will be shared between Wadsworth and NYU, where their extensive capabilities complement each other. The WC-CHEAR will benefit from the Wadsworth Center's international reputation and leadership in the field of clinical laboratory medicine, and as an organizer of proficiency testing (PT) programs in environmental laboratory medicine, clinical chemistry and toxicology. The experience and capability that Wadsworth brings in this regard will provide the NIEHS Children's Health Environmental Analytical Resource (CHEAR) network with a PT program customized to support biomonitoring studies and the needs of the network. The CHEAR PT program developed at Wadsworth will produce well-characterized, matrix-based reference materials containing exogenous and endogenous analytes of interest at critical concentration ranges relevant to biomonitoring that will be shared across the CHEAR lab network.