SWOG Biospecimen Bank

 描述(由申请人提供)：SWOG是美国国家癌症研究所(NCI)国家临床试验网络(NCTN)内的一个成人临床试验癌症小组。SWOG临床试验包括一系列癌症类型(例如，乳腺癌、肺癌、结肠癌、前列腺癌、白血病、黑色素瘤、淋巴瘤和多发性骨髓瘤)。SWOG生物菌素库(SWOG BB)位于国立儿童医院的生物病理学中心，旨在采购、加工、储存和分发作为NCI赞助的临床治疗试验的主要组成部分收集的生物菌素。这些生物样本与人口统计数据、手术和病理报告、治疗信息和随访数据相关联。这些生物检疫剂经审查和批准后，将优先分发给 临床试验方案。一旦这些需求得到解决，剩余的(遗留)储存的生物检疫剂就可以分发给SWOG内外的其他经批准的调查人员。世行是SWOG临床和转化医学计划的一个有效和可行的部分，专注于整合诊断、治疗、实验室和临床数据，以回答临床和转化性研究中的问题。SWOG BB的工作假设是，与分子签名/标记相关联的高质量、临床注释和与癌症相关的人类生物标本的库将极大地促进临床癌症研究。为了支持这一努力，SWOG BB使用基于当前生物仓库最佳实践和最新实验室技术的标准操作程序来管理这些生物检验品。因此， 银行能够保持准确和有效的肿瘤和正常样本资源，以及相关的临床、流行病学和受保护的健康信息。世行通过提供进入Biosecimen IT导航器和NCTN“前门”服务的途径，促进合格研究人员的研究。SWOG BB旨在协调和扩展一般银行实践和创新技术，促进分子生物学研究，并通过NCI赞助的集团银行委员会(GBC)增加研究人员对临床研究试验的参与。SWOG BB还建议扩大其基础设施，以支持参加NCI ETCTN临床试验的癌症患者的生物样本的银行、处理和分发。

 DESCRIPTION (provided by applicant): SWOG is an adult clinical trials cancer group within the National Clinical Trials Network (NCTN) of the National Cancer Institute (NCI). SWOG clinical trials include a range of cancer types (e.g., breast, lung, colon, prostate, leukemia, melanoma, lymphoma, and multiple myeloma). The SWOG Biospecimen Bank (SWOG BB), located in the Biopathology Center at Nationwide Children's Hospital, was designed to procure, process, bank, and distribute biospecimens collected as a major component of NCI sponsored clinical treatment trials. These biospecimens are linked to demographic data, surgical and pathological reports, treatment information, and follow-up data. These biospecimens, upon review and approval, are prioritized for distribution to the specific SWOG investigators defined in the clinical trial protocols. Once those needs have been addressed, residual (legacy) banked biospecimens can be distributed to other approved investigators within and outside SWOG. The Bank is a functioning and viable part of SWOG's clinical and translational medicine program, and focuses on the integration of diagnostic, therapeutic, laboratory, and clinical data to answer questions in clinical and translational research. The SWOG BB works under the hypothesis that banking of high quality, clinically-annotated and cancer-related human biospecimens, linked to molecular signatures/markers, will significantly facilitate clinical cancer research. To support ths effort, the SWOG BB manages these biospecimens using standard operating procedures based on current best practices for biorepositories and the latest laboratory technology. As a result the Bank is able to maintain an accurate and effective resource of tumor and normal samples with associated clinical, epidemiologic, and protected health information. The Bank promotes research by qualified investigators by providing access to the Biospecimen IT Navigator and the NCTN "front door" services. The SWOG BB aims to harmonize and expand general banking practices and innovative technologies facilitating molecular biology research and increase investigator participation in clinical research trials via the NCI sponsored Group Banking Committee (GBC). The SWOG BB also proposes to expand its infrastructure to support the banking, processing, and distribution of biospecimens from patients with cancer participating in NCI ETCTN Clinical Trials.