Sample and Data Management Core

摘要 样本和数据管理核心(SDMC)的主要目标是为每个 路易斯维尔超级基金中心的四个项目。核心的功能与每个人的需求相匹配 项目并涵盖从协作和日常服务到协议准备的全方位服务 程序性审查和监督。核心将提供两项主要服务：它将为 长期储存和存档样本和数据；它将协助中心调查人员进行统计 对他们的结果进行分析。核心将确保这些标本的真实性和质量，并将准备 这些样品用于长期储存，或根据需要分发样品。核心还将科学地提供 有效和严谨的数据统计分析，并支持开发创新的方法，以加强 中心研究人员的基础研究和翻译研究工作。核心将提供最先进的生物统计 以及生物信息学专业知识和分析支持。核心生物统计学家还将开发新的统计学 估计暴露人群心脏代谢性疾病风险的方法，如定量风险评估模型 并用于分析和评估暴露和健康后果。此外，核心 将开发新的方法来分析多种污染物暴露，因为它们与健康结果有关。这个 CORE将作为培训研究生、博士后研究员、住院医生的独特教育资源 和初级教员，并与培训和行政中心合作。此核心将允许中心 调查人员可轻松获得高质量、集中的数据管理和统计服务，从而将 增强中心的组织凝聚力。这项全面和综合的服务允许 或更多的生物统计学家从项目的初始规划阶段参与(当统计咨询是 最有益的)在整个实施、分析和完成过程中。核心将提供稳定和 培养生物统计员和调查人员之间长期工作关系的合伙环境，以及 继续推广实验设计和分析的复杂方法。这方面的生物统计学家 CORE精通临床研究，并在统计应用方面拥有广泛的专业知识 流行病学调查、临床试验、临床前研究和预防控制研究。他们的 与基础科学家和临床研究人员的跨学科互动将为 对实验结果的解释，只有当合作者相互欣赏时才有可能 一系列的问题和问题。

ABSTRACT The primary objective of the Sample and Data Management Core (SDMC) is to provide support to each of the four projects of the Louisville Superfund Center. The functions of the Core are matched to the needs of each project and cover a full range of services from collaboration and routine service to protocol preparation to procedural review and oversight. The Core will provide two main services: it will establish a repository for the long-term storage and archiving of samples and data; and it will assist Center investigators in the statistical analysis of their results. The core will assure the authenticity and quality of these specimens and it will prepare these samples for long-term storage, or dispense samples as needed. The Core will also provide scientifically valid and rigorous statistical analysis of data and support the development of innovative methods to enhance the basic and translational research efforts of Center investigators. The Core will provide state-of-the-art biostatistics and bioinformatics expertise and analytical support. Core biostatisticians will also develop new statistical methods, such as quantitative risk assessment models, for estimating cardiometabolic disease risk in exposed populations and for the analysis and evaluation of exposures and health consequences. In addition, the core will develop novel methods for the analysis of multi-pollutant exposures as they relate to health outcomes. The core will serve as a unique educational resource for training graduate students, post-doctoral fellows, residents and junior faculty and in collaboration with the Training and Administration Cores. This Core will allow Center investigators easy access to high quality, centralized data management and statistical services, and thereby will strengthen the organizational cohesion of the Center. This comprehensive and integrated service permits one or more biostatisticians to be involved from the initial planning stage of a project (when statistical consultation is most beneficial) throughout its implementation, analysis and completion. The Core will provide a stable and collegial environment that fosters long-term working relationships between biostatisticians and investigators, and continues to promote sophisticated approaches to experimental design and analysis. The biostatisticians of this Core are knowledgeable about clinical research and have broad expertise in statistical applications for epidemiological investigations, clinical trials, pre-clinical studies, and prevention and control research. Their interdisciplinary interactions with basic scientists and clinical investigators will add a new dimension to the interpretation of experimental results, one that is only possible when collaborators share a mutual appreciation of problems and issues.