Synthesis Core

项目总结 爱荷华大学的超级基金研究项目(ISRP)调查了 大气来源和接触半挥发性、低氯化的多氯联苯(多氯联苯)。这个 ISRP的生物医学和环境研究项目需要各种研究化合物，范围从 用于研究纯多氯联苯同系物及其代谢物的技术和合成多氯联苯混合物 这些多氯联苯同系物的挥发、运输和暴露。这些研究的一个主要障碍是 209种多氯联苯同系物加上837种可能的羟化(OH-多氯联苯)、硫酸化(多氯联苯) 硫酸盐)、葡萄糖醛酸化(多氯联苯葡萄糖醛酸化物)和其他多氯联苯代谢物。许多这些印刷电路板的衍生品是 从商业来源得不到或以前从未合成过。此外，获取印刷电路板 来自商业来源的混合物或单独的多氯联苯同系物可能很昂贵，特别是在大的情况下 动物研究需要大量的药物。因此，综合核心的主要目标是 为个别研究项目提供各种完全特性化和高纯度的印刷电路板衍生品 以及ISRP内的研究支持核心。如果时间和资源允许，合成核心也将使 研究化合物可供其他研究人员使用，特别是来自其他超级基金研究的研究人员 程序。同时，合成核心将继续开发新的合成策略 根据ISRP研究人员的需要合成多氯联苯同系物和多氯联苯代谢物。《公约》的具体目标 综合核心是1)维护和准备印刷电路板混合物和纯印刷电路板同系物；2)准备 羟基化的多氯联苯衍生物；合成多氯联苯硫酸盐代谢物；以及4)制备杂类化合物， 包括羟基多氯联苯、葡萄糖醛酸苷和重氮甲烷。综合核心研究人员经验丰富 完成ISRP研究项目要求的所有化合物的制备、提纯和表征。 多氯联苯混合物、个别羟基多氯联苯、多氯联苯硫酸盐和其他多氯联苯代谢物的及时供应将 大大增强，如果无法获得各自的多氯联苯代谢物，则能够进行创新研究 由ISRP研究项目提出。

PROJECT SUMMARY The Superfund Research Program at the University of Iowa (isrp) investigates the consequences of atmospheric sources and exposures to semi-volatile, lower-chlorinated polychlorinated biphenyls (PCBs). The biomedical and environmental research projects of the isrp need a variety of study compounds ranging from technical and synthetic PCB mixtures to pure PCB congeners and their metabolites for studies of the volatilization, transport and exposure of these PCB congeners. A major obstacle for these studies is the large number of 209 PCB congeners plus the large number of 837 possible hydroxylated (OH-PCBs), sulfated (PCB sulfates), glucuronidated (PCB glucuronides) and other PCB metabolites. Many of these PCB derivatives are not available from commercial sources or have never been synthesized before. Moreover, obtaining PCB mixtures or individual PCB congeners from commercial sources can be expensive, especially if large quantities are needed for animal studies. Therefore, the MAJOR OBJECTIVE of the Synthesis Core is to provide a large variety of fully characterized and highly pure PCB derivatives to individual research projects and research support cores within the isrp. If time and resources allow, the Synthesis Core will also make study compound available to other researchers, especially researchers from other Superfund Research Programs. At the same time, the Synthesis Core will continue to develop novel synthetic strategies for the synthesis of PCB congeners and PCB metabolites as needed by isrp researchers. The Specific Aims of the Synthesis Core are to 1) maintain and prepare PCB mixtures and pure PCB congeners; 2) prepare hydroxylated PCB derivatives; synthesize PCB sulfate metabolites; and 4) prepare miscellaneous compounds, including OH-PCB glucuronides and diazomethane. Synthesis Core researchers have extensive experience with the preparation, purification and characterization of all compounds requested by isrp research projects. The timely availability of PCB mixtures, individual OH-PCBs, PCB sulfates and other PCB metabolites will greatly enhance and, if the respective PCB metabolites are unavailable, enable the innovative studies proposed by isrp research projects.