University of New Mexico Cancer Center Support Grant

 描述(由申请人提供)：癌症控制(CAC)研究计划是一个新重组的跨学科计划，它是新墨西哥州大学癌症中心(UNCC)和新墨西哥州(NM)的癌症控制和人口科学研究的枢纽，新墨西哥州是我们的集聚地区。该计划的总体目标是降低癌症发病率、发病率和死亡率，特别是在新墨西哥州独特的多种族和服务不足的人群中。差异研究是一个交叉主题，促进各研究领域的科学重点和协同作用。通过积极的战略规划和评估，招募9名新的调查人员以提高分子流行病学和行为/社区干预方面的专业知识，以及联合国儿童基金会外部咨询委员会的指导，CAC计划目前专注于癌症研究的三个领域：1)风险预测和降低风险；2)筛查；以及3)诊断后结果和生存。独特的科学优势包括针对差异(地理、种族/民族、社会经济、医疗服务不足)的研究，特别是在拉美裔的病因、结果和干预研究方面。通过利用已建立的和新的伙伴关系，该计划还在建立研究，以解决NM部落、普韦布洛斯人和印第安人确定的美洲印第安人癌症差异和优先事项。风险预测和降低风险方面的主要科学成就包括识别与肺癌风险相关的社会、生活方式和遗传因素；黑色素瘤风险中的基因-环境相互作用；以及用于预防肝细胞癌的新型远程保健策略的开发和传播。在筛查方面，成员们制定了一项全州范围的宫颈癌前病变和癌症筛查和诊断监测计划，通过接种人乳头瘤病毒(HPV)疫苗、筛查实践和结果，为现实世界中的宫颈癌预防提供信息。成员们还确定了在结直肠癌中使用早期检测测试的障碍，并制定了克服这些障碍的战略，以改善在服务不足的人群中的筛查。在诊断后结果和生存方面，成员们已经确定了导致子宫内膜癌和乳腺癌治疗后结果和存活率差异的因素，并正在制定干预措施。CAC计划由Linda Cook博士和Anita Kinney博士领导，由28名成员(19名正式成员和9名助理成员)组成，来自7所UNM学校和科室、Lovelace呼吸研究所和疾病控制中心印度卫生服务部，他们的工作得到了192.768.63亿美元的年度直接成本资金的支持，其中154.299.11亿美元来自同行审查，31.378.2亿美元来自NCI。该计划的发现产生了294份出版物，其中19%是方案内合作，16%是计划间合作；方案协调委员会和外部合作出版的总水平分别为30%和80%。

 DESCRIPTION (provided by applicant): The Cancer Control (CaC) Research Program is a newly restructured transdisciplinary program that serves as the hub for cancer control and population science research within the University of New Mexico Cancer Center (UNMCC) and the State of New Mexico (NM), our catchment area. The Program's overall goal is to reduce cancer incidence, morbidity, and mortality, particularly in the unique multiethnic and underserved populations of NM. Disparities research is a cross-cutting theme that fosters scientific focus and synergy across the research areas. Through vigorous strategic program planning and evaluation, recruitment of 9 new investigators to enhance expertise in molecular epidemiology and behavioral/community intervention, and guidance of the UNMCC External Advisory Committee, the CaC Program is now focused on three areas of cancer research: 1) Risk Prediction and Risk Reduction; 2) Screening; and 3) Post-Diagnosis Outcomes and Survivorship. Unique scientific strengths include research addressing disparities (geographic, race/ethnic, socioeconomic, medically underserved), particularly in etiologic, outcome, and intervention studies in Hispanics. By drawing on established and new partnerships, the Program is also building research that addresses American Indian cancer disparities and priorities identified by NM Tribes, Pueblos, and Indian Nations. Major scientific accomplishments in Risk Prediction and Risk Reduction include the identification of social, lifestyle, and genetic factors associated with lung cancer risk; gene-environment interactions in melanoma risk; and development and dissemination of a novel telehealth strategy for the prevention of hepatocellular cancer. In Screening, members have developed a statewide surveillance program of screening and diagnosis for cervical pre-cancer and cancer that informs real- world cervical cancer prevention through human papilloma virus (HPV) vaccination, screening practice and outcomes. Members have also identified barriers to use of early detection tests in colorectal cancer and have developed strategies to overcome these barriers to improve screening in underserved populations. In Post- Diagnosis Outcomes and Survivorship, members have identified factors that contribute to disparities in post- treatment outcomes and survivorship in endometrial and breast cancer and are developing interventions. Led by Linda Cook, Ph.D. and Anita Kinney, Ph.D., RN, the CaC Program is comprised of 28 members (19 full and 9 associate) from 7 UNM schools and departments, the Lovelace Respiratory Institute, and the Indian Health Service Unit of the Centers for Disease Control whose work is supported by $19,276,863 million in annual direct cost funding, of which $15,429,911 million is peer-reviewed and $3,137,820 million is from NCI as of 9/1/2014. The discoveries made in this Program have resulted 294 publications, of which 19% are intra-programmatic collaborations and 16% are inter-programmatic collaborations; with a total UNMCC and external collaborative publication level of 30% and 80%, respectively.