Mayo Comprehensive Cancer Center Grant (MICEO Supp) - Impact of Multi-Channel Communication Campaigns on Cancer Prevention, Control and Survivorship (CaPCaS) in Black, Hispanic, and Rural Populations

梅奥综合癌症中心拨款 (MICEO Supp) - 多渠道沟通活动对黑人、西班牙裔和农村人口癌症预防、控制和生存 (CaPCaS) 的影响

• 批准号: 10889628
• 负责人: CHERYL LYNN WILLMAN
• 金额: $ 20万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10889628
• 关键词: Administrative Supplement; Adoption; Advocate; Arizona; Attitude; Awareness; Behavior; Behavioral; Black Populations; Breast; Cancer Advocacy; Cancer Center Support Grant; Cancer Death Rates; Catchment Area; Clinic; Clinical Trials; Colorectal; Colorectal Cancer; Communication; Communities; Community Health; Community Outreach; Comprehensive Cancer Center; Continuity of Patient Care; Death Rate; Education; Florida; General Population; Geography; Goals; Grant; Health; Health Educators; Health Professional; Health system; Hispanic; Hispanic Populations; Intention; Knowledge; Life Style; Lung; Malignant Neoplasms; Malignant neoplasm of liver; Malignant neoplasm of lung; Malignant neoplasm of prostate; Midwestern United States; Pancreas; Population; Prevention; Preventive; Prostate; Public Health; Research Personnel; Rural Population; Scientist; Site; Survivors; Target Populations; Training; aged; black men; cancer care; cancer health disparity; cancer prevention; community engagement; evidence base; genetic testing; handbook; health communication; health equity; implementation science; improved; innovation; literacy; mortality; programs; response; screening; survivorship

ABSTRACT This application is being submitted by the Mayo Clinic Comprehensive Cancer Center (MCCCC) in response to the “Administrative Supplements for the NCI P30 Cancer Center Support Grants for Multi-Channel Communication Campaigns”. The MCCCC community outreach and engagement activities are led by the MCCCC Community Outreach & Engagement (COE) Office and Programs in three MCCCC catchment areas (CAs), including Arizona (AZ), Florida (FL) and the Midwest/Mayo Clinic Health Systems (MCHS). Although our 3-site catchment areas (CAs) are unique communities, the top cancers at each site are lung, breast, prostate, colorectal and pancreas. However, cancer disparities are uniquely different for the priority populations. In AZ CA, the targeted cancers are colorectal cancer (CRC) and liver cancer. Hispanics are twice likely to die from liver cancer compared to NH Whites. Although the CRC mortality rate is similar for both Hispanic and NH Whites, the CRC mortality rate for AZ CA Hispanics is elevated compared to US Hispanics. In FL CA, the targeted cancer is prostate cancer (CaP) in NH Black men. CaP leads cancer mortality among NH Blacks in the FL CA. Black men are twice as likely to die from CaP. The CaP death rate for Black men in FL is also elevated compared to the death rate for US Black men. In the Midwest/MCHS CA, the targeted cancers are lung, prostate, and colorectal cancers. These cancers are three of the top five cancers in the CA. The proposed supplement project focuses on Track 2, targeting the general population aged 30 years and above. Multi-channel communication campaigns will be delivered by Community Health Educators (CHEs) across the cancer care continuum and tailored to each of the MCCCC CAs. The primary goal of the supplement is to assess the impact of multi-channel communication campaigns targeting Black, Hispanic, and Rural populations on cancer prevention, control and survivorship (CaPCaS). This goal will be achieved through three specific aims: (1) Using the MCCCC Cancer Advocacy Handbook, train 15 (5 at each site) cancer advocates/survivors to lead the CaPCaS communication campaigns as CHEs, focusing primarily on improving cancer health and clinical trials literacy, increasing awareness about cancer prevention, screenings and genetic testing, and promoting preventive lifestyle behaviors; Adapt and implement evidence-based and innovative, culturally tailored, multi-channel educational communication campaigns tailored to Black men in FL CA, Hispanics in AZ CA and rural populations in the Midwest/MCHS geographies; and Evaluate the impact of the CaPCaS campaigns relative to increasing CaPCaS-related knowledge, attitudes, behavioral intention and adoption of prevention behavior.The academic-community team assembled for this project is comprised of health equity scientists, behavioral scientists (including implementation science researchers), clinician scientists, and public health professionals with significant expertise in health communications. (2) (3)

摘要 本申请由马约诊所综合癌症中心（MCCC）提交， 对“NCI P30癌症中心多渠道支持赠款的行政补充”的回应 宣传运动”。MCCC社区外展和参与活动由 MCCC社区外展和参与（COE）办公室和三个MCCC集水区的计划 (CAs)包括亚利桑那州（AZ）、佛罗里达州（FL）和中西部/马约诊所卫生系统（MCHS）。虽然我们的 3-站点集水区（CA）是独特的社区，每个站点的顶级癌症是肺癌，乳腺癌，前列腺癌， 结肠直肠和胰腺。然而，癌症的差异对于优先人群来说是独特的。在AZ CA，靶向癌症是结肠直肠癌（CRC）和肝癌。西班牙裔人死于 肝癌与白色相比。尽管西班牙裔和NH白人的CRC死亡率相似， 与美国西班牙裔相比，AZ CA西班牙裔的CRC死亡率升高。在FL CA中，靶向癌症 前列腺癌（CaP）在美国黑人男性。CaP在FL CA的NH黑人中导致癌症死亡率。黑色 男性死于前列腺癌的几率是男性的两倍佛罗里达州黑人的CaP死亡率也高于 美国黑人的死亡率在中西部/MCHS CA，靶向癌症是肺癌、前列腺癌和 结肠直肠癌这些癌症是CA五大癌症中的三种。 拟议的补充项目侧重于轨道2，针对30岁以上的一般人群 及以上社区健康教育工作者将开展多渠道宣传活动 整个癌症护理连续体，并为每个MCCC CA量身定制。补充的主要目的 评估针对黑人、西班牙裔和农村的多渠道宣传活动的影响 癌症预防、控制和存活率（CaPCaS）。这一目标将通过三个 具体目标： （一） 使用MCCC癌症宣传手册，培训15名（每个研究中心5名）癌症 倡导者/幸存者作为CHE领导CaPCaS宣传活动，主要侧重于改善 癌症健康和临床试验知识，提高对癌症预防，筛查和遗传学的认识 测试和促进预防性生活方式行为;适应和实施基于证据和创新的， 为加利福尼亚州佛罗里达州的黑人男子量身定制的文化定制的多渠道教育宣传活动， AZ CA的西班牙裔和中西部/MCHS地区的农村人口;并评估 CaPCaS运动相对于增加CaPCaS相关知识，态度，行为意图和 采取预防行为。为这个项目聚集的学术社区团队由健康 公平科学家，行为科学家（包括实施科学研究人员），临床科学家，以及 公共卫生专业人员在卫生传播方面具有重要的专业知识。 （二） （三）

项目成果

Epigenetic alteration contributes to the transcriptional reprogramming in T-cell prolymphocytic leukemia.

• DOI: 10.1038/s41598-021-87890-9
• 发表时间: 2021-04-15
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Tian S;Zhang H;Zhang P;Kalmbach M;Lee JH;Ordog T;Hampel PJ;Call TG;Witzig TE;Kay NE;Klee EW;Slager SL;Yan H;Ding W
• 通讯作者: Ding W

Prediagnostic alcohol consumption and colorectal cancer survival: The Colon Cancer Family Registry.

• DOI: 10.1002/cncr.30446
• 发表时间: 2017-05-15
• 期刊: Cancer
• 影响因子: 6.2
• 作者: Phipps AI;Robinson JR;Campbell PT;Win AK;Figueiredo JC;Lindor NM;Newcomb PA
• 通讯作者: Newcomb PA

Antitumor effect of FGFR inhibitors on a novel cholangiocarcinoma patient derived xenograft mouse model endogenously expressing an FGFR2-CCDC6 fusion protein.

• DOI: 10.1016/j.canlet.2016.05.017
• 发表时间: 2016-09-28
• 期刊: CANCER LETTERS
• 影响因子: 9.7
• 作者: Wang, Yu;Ding, Xiwei;Wang, Shaoqing;Moser, Catherine D.;Shaleh, Hassan M.;Mohamed, Essa A.;Chaiteerakij, Roongruedee;Allotey, Loretta K.;Chen, Gang;Miyabe, Katsuyuki;McNulty, Melissa S.;Ndzengue, Albert;Fritcher, Emily G. Barr;Knudson, Ryan A.;Greipp, Patricia T.;Clark, Karl J.;Torbenson, Michael S.;Kipp, Benjamin R.;Zhou, Jie;Barrett, Michael T.;Gustafson, Michael P.;Alberts, Steven R.;Borad, Mitesh J.;Roberts, Lewis R.
• 通讯作者: Roberts, Lewis R.

Alcohol Consumption and the Risk of Colorectal Cancer for Mismatch Repair Gene Mutation Carriers.

• DOI: 10.1158/1055-9965.epi-16-0496
• 发表时间: 2017-03
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
• 作者: Dashti SG;Buchanan DD;Jayasekara H;Ait Ouakrim D;Clendenning M;Rosty C;Winship IM;Macrae FA;Giles GG;Parry S;Casey G;Haile RW;Gallinger S;Le Marchand L;Thibodeau SN;Lindor NM;Newcomb PA;Potter JD;Baron JA;Hopper JL;Jenkins MA;Win AK
• 通讯作者: Win AK

Multi-trait genome-wide association study identifies a novel endometrial cancer risk locus that associates with testosterone levels.

• DOI: 10.1016/j.isci.2023.106590
• 发表时间: 2023-05-19
• 期刊: ISCIENCE
• 影响因子: 5.8
• 作者: Wang, Xuemin;Kho, Pik Fang;Ramachandran, Dhanya;Bafligil, Cemsel;Amant, Frederic;Goode, Ellen L.;Scott, Rodney J.;Tomlinson, Ian;Evans, D. Gareth;Crobie, Emma J.;Doerk, Thilo;Spurdle, Amanda B.;Clubb, Dylan M.;O'Mara, Tracy A.
• 通讯作者: O'Mara, Tracy A.