Pediatric Pathology Translational Research

描述（由申请人提供）：这是一个露丝L修改后的申请。Kirschstein Institutional National Research Service Award（NRSA/T32）是为医学博士，医学博士/博士和博士研究员的博士后研究培训而开发的，他们准备在转化儿科病理学研究中担任独立研究员。特别注重研究 研究儿童中特别普遍的心脏、肺或血液疾病的病理生理学。该计划提案包括转化医学、人类受试者研究、研究道德行为以及基因组学和蛋白质组学等创新技术方面的正式教学培训，以及在学术丰富的环境中获得指导性研究经验，该环境得到了波士顿儿童医院和哈佛催化剂临床转化科学中心（CTSC）提供的众多教育和职业发展资源的支持。培训计划以波士顿儿童医院病理科为中心，由波士顿儿童医院、布里格姆妇女医院、哈佛医学院和布罗德研究所其他科室的翻译研究人员组成的研究小组为研究人员提供支持。为了加强该计划的协作，转化病理学性质，学员还需要借鉴临床儿科病理学教师的经验，并鼓励利用大量的冷冻和福尔马林固定，石蜡包埋的组织资源部门为他们的研究。最重要的是，该计划的首要目标是赋予下一代翻译儿科病理学家的技能，以促进创新的诊断和治疗儿科疾病。

DESCRIPTION (provided by applicant): This is a revised application for a Ruth L. Kirschstein Institutional National Research Service Award (NRSA/T32) developed for post-doctoral research training for MD, MD/PhD, and PhD fellows preparing for a career as an independent investigator in translational pediatric pathology research. There is a particular focus on research into the pathophysiology of disorders of the heart, lung or blood that are particularly prevalent i children. The Program proposal includes formal didactic training in translational medicine, human subjects research, the ethical conduct of research, and innovative technologies such as genomics and proteomics as well as a mentored research experience in an academically rich environment that is supported by numerous educational and career development resources provided by Children's Hospital Boston and the Harvard Catalyst Clinical Translational Sciences Center (CTSC). The Training Program centers around the Department of Pathology at Children's Hospital Boston and involves its research faculty supported by a select group of translational investigators from other Departments at Children's Hospital Boston, the Brigham and Women's Hospital, Harvard Medical School, and the Broad Institute. To enhance the collaborative, translational pathology nature of the Program, trainees are also required to draw upon the experience of the clinical pediatric pathology faculty and are encouraged to utilize the substantial frozen and formalin-fixed, paraffin-embedded tissue resources of the Department for their studies. Above all, the overriding goal of the Program is to endow the next generation of translational pediatric pathologists with the skills to contribute to innovative diagnostics and treatment of pediatric diseases.