Einstein's Nathan Shock Center of Excellence in Basic Biology of Aging

描述（由申请人提供）：这是第一次竞争性更新的变革爱因斯坦内森休克中心（E-NSC）。在第一个赠款期间，专门用于衰老生物学的资金规模增加了两倍，并伴随着令人印象深刻的出版物记录E-NSC成员，例如在自然和科学期刊上发表的124篇论文和评论，平均约有6篇合作论文，（与其他欧洲国家安全委员会成员一起），并积极征聘25名首次提交报告时不是欧洲国家安全委员会成员的成员并将其“转换”为欧洲国家安全委员会成员。我们的成员现在包括内部（52）和外部（11）的成员，以及与布朗大学（5）调查员的“迷你国家安全委员会”的支持。其他资源对于E-NSC的成功也非常重要，包括大型老龄化计划项目，正在进行的NIH资助的爱因斯坦老龄化（T32）培训补助金，关于衰老生物学的补充研究生课程，以及爱因斯坦的格伦人类衰老生物学中心。E-NSC的活动得到了补充机构资金的杠杆作用;该中心授予了18个试点和可行性赠款，取得了良好的成果。这三个研究资源中心为150多名研究人员提供服务，以合理的价格提供最先进的服务和可靠的质量控制。 欧洲国家安全理事会的目标是： 1)通过为我们的三个研究资源核心提供最先进和独特的新技术，加强和扩大正在进行的衰老基础生物学研究： a）Proteostasis of Aging Core（PAC，Dr. Ana Maria Cuervo）; B）衰老核心的时间生物学、能量学/代谢（CEAC，Nir Barzilai和Derek霍夫曼博士）; （c）Advanced Genomics of Aging Core（AGAC，Dr. Jan Vijg）。 2)行政核心（Barzilai博士）通过系列讲座、小型务虚会和出席国家安全委员会的国家会议，执行和管理丰富活动，并将继续开发潜在的区域和/或国家资源。 3)通过研究发展核心（Dr. Yousin Suh）为衰老生物学研究的新研究人员提供支持和合适的环境，该核心将为值得研究的研究人员提供P&F奖。

DESCRIPTION (provided by applicant): This is the first competitive renewal for the transformative Einstein Nathan Shock Center (E-NSC). During the first grant period, funding exclusively for biology of aging tripled in size, and was accompanied by an impressive publications record E-NSC members as exemplified in 124 papers and reviews in Nature and Science-journals, a staggering average of approximately 6 collaborative papers (with other E-NSC members) per E-NSC investigator and the proactive recruitment and 'conversion' of 25 members to the E-NSC who were not members for the first submission. Our membership now includes internal (52) and external (11) members as well as support for a 'mini-NSC' with Brown University (5) investigators. Other resources are also highly important for E-NSC success, including large aging Program Projects, an ongoing NIH-funded Einstein Aging (T32) training grant, a complementary graduate course on the Biology of Aging, and the Glenn Center for Biology of Human Aging at Einstein. Activities of the E-NSC were leveraged by supplemental Institutional funding; the Center awarded 18 pilot and feasibility grants, with good outcomes. The three Research Resource Cores provided services to over 150 investigators, offering state-of the art services with dependable quality control at an affordable price. The aims of the E-NSC are: 1) To enhance and expand ongoing basic biology of aging research by providing state of the art and unique new technologies for our three Research Resource Cores: a) Proteostasis of Aging Core (PAC, Dr. Ana Maria Cuervo); b) Chronobiosis, Energetics/Metabolism of Aging Core (CEAC, Drs. Nir Barzilai and Derek Huffman); c) Advanced Genomics of Aging Core (AGAC, Dr. Jan Vijg). 2) The Administrative Core (Dr. Barzilai) implements and administers enrichment activities through a lecture series, mini-retreats and attendance at NSC national meetings, and will continue to develop potential regional and/or national resources. 3) To provide support and a suitable environment for new investigators in biology of aging research through a Research Development Core (Dr. Yousin Suh) that will provide P&F awards to deserving investigators.