Molecular and Biochemistry Core Facility

摘要-核心C 分子和生物化学核心设施将提供关键服务，以支持以下科学目标： 该计划项目;即RAS和RAS相关基因，蛋白质和生物化学的分析， 心肌液组织和细胞所有分析将由与样品相关的经过培训的人员进行。的 对这些服务采取互补和统一的办法，将使调查结果 在不同组织、物种和性别之间进行比较和对比。这是一个重要的资产为拟议的 作为项目1和2的研究者，研究开始表征全身和心脏RAS的表达 在表达人型血管紧张素原[TGR（hAGT）L1623]和人糜酶的转基因大鼠中， (hCHY Tg+）。

Summary - Core C The Molecular and Biochemistry Core Facility will provide critical services to support the scientific goals of this Program Project; namely, the analysis of RAS and RAS-related genes, proteins, and biochemistry in myocardial fluid, tissue, and cells. All analyses will be done by trained personnel linked to the samples. The implementation of a complementary and uniform approach to these services will allow findings to be compared and contrasted across tissues, species, and sexes. This is a significant asset for the proposed studies as investigators in Project 1 and 2 begin to characterize the expression of systemic and cardiac RAS in transgenic rats expressing the human forms of angiotensinogen [TGR(hAGT)L1623] and human chymase (hCHY Tg+).