Growth Hormone, Angiotensin II, and Cardiac Aging

生长激素、血管紧张素 II 和心脏衰老

• 批准号: 7452239
• 负责人: LEANNE GROBAN
• 金额: $ 17.5万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-15 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7452239
• 关键词: Adult; Age; Age-Months; Aging; Aldosterone; Anesthesiology; Angiotensin II; Angiotensins; Attenuated; Award; Basic Science; Biochemical; Blood capillaries; Blood flow; Cardiac; Cardiology; Cardiovascular system; Caring; Clinical; Collagen; Congestive Heart Failure; Coronary; Data; Development; Development Plans; Diastolic heart failure; Disease; Doctor of Medicine; Education; Environment; Enzymes; Equilibrium; Exhibits; Extracellular Matrix; Fellowship; Fibrosis; Foundations; Functional disorder; Goals; Heart; Heart failure; Hypertension; Impairment; Insulin; Insulin-Like Growth Factor I; K-Series Research Career Programs; Knowledge; Left; Left Ventricular Remodeling; Light; Mediating; Microfilaments; Modeling; Molecular; Molecular and Cellular Biology; Myocardial; Papillary; Pathogenesis; Pathway interactions; Patients; Performance; Pharmacology; Physiologic pulse; Physiological; Physiology; Pulse taking; Rattus; Regulation; Rehabilitation therapy; Relaxation; Renin; Renin-Angiotensin System; Research; Research Institute; Research Personnel; Research Technics; Risk; Rodent; Role; Site; Somatotropin; Structure; Supplementation; System; Testing; Tissues; Training; Ventricular; Withdrawal; age related; aged; base; capillary; career; cohort; density; early onset; genetic regulatory protein; heart circulation; improved; interest; interstitial; normal aging; novel; older patient; programs; receptor; senescence; statistics

The candidate for the Paul B. Beeson Career Development Award in Aging was awarded the M.D. degree and received post-graduate fellowship training in cardiothoracic anesthesiology. The candidate has chosen to combine her cardiovascular background and interest in aging to study mechanisms of diastolic dysfunction related to aging. To this end, the candidate participated in the NIA Summer Research Institute and was subsequently awarded an R03 and the Dennis Jahnigen Career Development Award to examine the role of Insulin-like Growth Factor-1 (IGF-1) in Diastolic Dysfunction, which is the basis for the current career development plan. The proposed award will enable the candidate to accomplish the following objectives: 1) expand her scientific knowledge and research techniques in aging; 2) define a potential mechanism of diastolic dysfunction of aging; and 3) allow the candidate to independently plan and conduct basic research in aging. The research plan will facilitate the candidate's accomplishment of these goals by providing opportunities for advanced education in the physiology of aging, molecular and cellular biology, statistics, and a seminar on responsible conduct in research. The candidate will be directed in her efforts by an interdisciplinary group of investigators in hypertension, cardiology, physiology and pharmacology. Opportunities will be available for the candidate to present and discuss research in progress with young investigators affiliated with the Hypertension Center and the J. Paul Sticht Center of Aging and Rehabilitation. Within this environment, the candidate will characterize age-related changes in circulating and intracardiac renin-angiotensin (RAS) systems as they relate to the structural and functional changes in the aged rodent heart. The contribution of GH/IGF-1 senescence to diastolic dysfunction and the balance of RAS, specifically ACE and ACE2, will be explored. The functional role of RAS in the control of cardiac remodeling and diastolic performance will be examined using RAS-inhibition and GH supplementation. This award will provide a foundation for the development of the candidate as an independent clinician-investigator in aging, and the study results will ultimately contribute to improvement of the care of the elderly patient.

保罗·B·比森老年职业发展奖的候选人被授予医学博士学位，并接受了心胸麻醉学研究生奖学金培训。这位候选人选择将她的心血管背景和对衰老的兴趣结合起来，研究与衰老相关的舒张期功能障碍的机制。为此，候选人参加了NIA夏季研究所，随后被授予R03和Dennis Jahnigen职业发展奖，以研究胰岛素样生长因子-1(IGF-1)在舒张期功能障碍中的作用，这是当前职业发展计划的基础。拟议的奖励将使候选人能够实现以下目标：1) 扩大她在老龄化方面的科学知识和研究技术；2)确定一个潜在的衰老的舒张性功能障碍的机制；以及3)允许候选人独立计划和进行老龄化的基础研究。该研究计划将通过提供在衰老生理学、分子和细胞生物学、统计学方面的高级教育机会，以及关于负责任的研究行为的研讨会，促进候选人实现这些目标。候选人将在高血压、心脏病学、生理学和药理学的跨学科研究小组的指导下努力。 候选人将有机会介绍正在进行的研究，并与隶属于高血压中心和J.Paul Sticht老龄化和康复中心的年轻研究人员讨论。在这种环境下，候选人将描述循环和心脏内肾素-血管紧张素(RAS)系统的年龄相关变化，因为它们与老年啮齿动物心脏的结构和功能变化有关。将探讨GH/IGF-1衰老在舒张期功能障碍和RAS平衡中的作用，特别是ACE和ACE2。RAS在控制心脏重构和舒张期功能中的作用将通过RAS抑制和GH补充来检验。这一奖项将为候选人发展成为老年领域的独立临床医生兼调查员奠定基础，研究结果最终将有助于改善老年患者的护理。