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Growth Hormone, Angiotensin II, and Cardiac Aging

生长激素、血管紧张素 II 和心脏衰老

基本信息

批准号：
7633196
负责人：
LEANNE GROBAN
金额：
$ 17.5万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-07-15 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7633196
关键词：
Adult Age Age-Months Aging Aldosterone Anesthesiology Angiotensin II Angiotensins Attenuated Award Basic Science Biochemical Blood capillaries Blood flow Cardiac Cardiology Cardiovascular system Caring Clinical Collagen Congestive Heart Failure Coronary Data Development Development Plans Diastolic heart failure Disease Doctor of Medicine Education Environment Enzymes Equilibrium Exhibits Extracellular Matrix Fellowship Fibrosis Foundations Functional disorder Goals Heart Heart failure Hypertension Impairment Insulin Insulin-Like Growth Factor I K-Series Research Career Programs Knowledge Left Left Ventricular Remodeling Light Mediating Microfilaments Modeling Molecular Molecular and Cellular Biology Myocardial Papillary Pathogenesis Pathway interactions Patients Performance Pharmacology Physiologic pulse Physiological Physiology Rattus Regulation Rehabilitation therapy Relaxation Renin Renin-Angiotensin System Research Research Institute Research Personnel Research Technics Risk Rodent Role Site Somatotropin Structure Supplementation System Testing Tissues Training Ventricular Withdrawal age related aged base capillary career development cohort density early onset genetic regulatory protein heart circulation improved interest interstitial normal aging novel older patient programs receptor senescence statistics

项目摘要

The candidate for the Paul B. Beeson Career Development Award in Aging was awarded the M.D. degree and received post-graduate fellowship training in cardiothoracic anesthesiology. The candidate has chosen to combine her cardiovascular background and interest in aging to study mechanisms of diastolic dysfunction related to aging. To this end, the candidate participated in the NIA Summer Research Institute and was subsequently awarded an R03 and the Dennis Jahnigen Career Development Award to examine the role of Insulin-like Growth Factor-1 (IGF-1) in Diastolic Dysfunction, which is the basis for the current career development plan. The proposed award will enable the candidate to accomplish the following objectives: 1) expand her scientific knowledge and research techniques in aging; 2) define a potential mechanism of diastolic dysfunction of aging; and 3) allow the candidate to independently plan and conduct basic research in aging. The research plan will facilitate the candidate's accomplishment of these goals by providing opportunities for advanced education in the physiology of aging, molecular and cellular biology, statistics, and a seminar on responsible conduct in research. The candidate will be directed in her efforts by an interdisciplinary group of investigators in hypertension, cardiology, physiology and pharmacology. Opportunities will be available for the candidate to present and discuss research in progress with young investigators affiliated with the Hypertension Center and the J. Paul Sticht Center of Aging and Rehabilitation. Within this environment, the candidate will characterize age-related changes in circulating and intracardiac renin-angiotensin (RAS) systems as they relate to the structural and functional changes in the aged rodent heart. The contribution of GH/IGF-1 senescence to diastolic dysfunction and the balance of RAS, specifically ACE and ACE2, will be explored. The functional role of RAS in the control of cardiac remodeling and diastolic performance will be examined using RAS-inhibition and GH supplementation. This award will provide a foundation for the development of the candidate as an independent clinician-investigator in aging, and the study results will ultimately contribute to improvement of the care of the elderly patient.

保罗B的候选人。Beeson老龄化职业发展奖被授予医学博士。学位，并接受了心胸麻醉学研究生奖学金培训。候选人选择联合收割机她的心血管背景和对衰老的兴趣来研究与衰老相关的舒张功能障碍的机制。为此，候选人参加了NIA夏季研究所，随后被授予R 03和Dennis Jahnigen职业发展奖，以研究胰岛素样生长因子-1（IGF-1）在舒张功能障碍中的作用，这是当前职业发展计划的基础。建议的奖项将使候选人实现以下目标：1）扩展她在衰老方面的科学知识和研究技术; 2）定义衰老舒张功能障碍的潜在机制; 3）允许候选人独立计划和进行衰老基础研究。研究计划将通过提供在衰老生理学、分子和细胞生物学、统计学方面的高级教育机会以及关于负责任的研究行为的研讨会，促进候选人实现这些目标。候选人的工作将由高血压、心脏病学、生理学和药理学领域的跨学科研究人员小组指导。候选人将有机会与高血压中心和J. Paul Sticht老龄化和康复中心的年轻研究人员一起展示和讨论正在进行的研究。在该环境中，候选人将描述循环和心内肾素-血管紧张素（RAS）系统中与年龄相关的变化，因为它们与老年啮齿动物心脏的结构和功能变化有关。将探讨GH/IGF-1衰老对舒张功能障碍和RAS平衡的作用，特别是ACE和ACE 2。将使用RAS抑制和GH补充来检查RAS在控制心脏重塑和舒张性能中的功能作用。该奖项将为候选人作为老龄化独立临床研究者的发展奠定基础，研究结果最终将有助于改善老年患者的护理。