The NYU Women's Health Study

 描述(由申请人提供)：纽约大学女性健康研究(NYUWHS)是一项前瞻性队列研究，研究对象是1985-1991年在纽约市一家乳腺癌筛查诊所登记的14,274名健康女性。除了生殖因素、病史和生活方式的数据外，这项研究还收集了登记时所有参与者的血清样本。超过一半的女性在随后的乳腺癌筛查中也收集了血清样本。所有研究参与者都可以获得DNA。到目前为止，NYUWHS已经出版了170多份出版物，其中57份是自2010年以来出版的。NYUWHS发起或参与了乳腺癌、子宫内膜癌、结直肠癌、卵巢癌、肺癌、胰腺癌、肾癌、肝脏癌和非霍奇金淋巴瘤(NHL)的研究。所研究的暴露包括饮食、生殖因素以及激素、饮食标记物、细胞因子和其他生物标记物的循环水平。NYUWHS还参与了胰腺癌、非霍奇金淋巴瘤和神经胶质瘤的全基因组关联研究。最后，NYUWHS获得了资金，用于进行心血管疾病研究，NYUWHS的数据推动了新统计方法的发展。这一应用程序的目的是维护和加强研究的基础设施。其具体目标是：1)通过主动和被动两种方式继续确诊癌症病例；2)通过跟踪调查问卷更新暴露数据，包括饮食和户外步行；3)收集主要癌症部位(乳腺癌、结直肠癌、子宫内膜和肺部)的肿瘤块，以便根据分子亚型评估危险因素；4)收集和验证社区步行方面的数据。持续的后续行动预计将确定另外1389例癌症病例，收集肿瘤块将提高这项研究的价值，收集有关社区步行能力的数据也是如此。NYUWHS有几个特定的优势。首先，在注册时收集的血清和DNA可供所有参与者使用，使生物信息库成为研究遗传变异、生物标记物和疾病风险之间关系的宝贵资源。其次，超过一半的参与者可以获得重复血清样本，这对于评估和提高循环标志物的时间可靠性非常有价值。第三，虽然几个大型癌症队列在50岁时开始登记，但纽约大学的6659名参与者登记/献血时的年龄为50岁，这为研究年轻女性中的癌症风险因素提供了机会。最后，纽约市是一个特别适合进行步行研究的地方，因为不同社区的步行范围很大。

 DESCRIPTION (provided by applicant): The NYU Women's Health Study (NYUWHS) is a prospective cohort study of 14,274 healthy women who were enrolled in 1985-1991 at a breast cancer screening clinic in New York City. In addition to data on reproductive factors, medical history and lifestyle, the study collected serum samples from all participants at enrollment. Serum samples were also collected at subsequent breast cancer screening visits from over half the women. DNA is available for all study participants. To date, the NYUWHS has led to over 170 publications, 57 since 2010. The NYUWHS has initiated or participated in studies of cancer of the breast, endometrium, colorectum, ovary, lung, pancreas, kidney, liver and non-Hodgkin lymphoma (NHL). Exposures studied include diet, reproductive factors, and circulating levels of hormones, dietary markers, cytokines, and other biomarkers. The NYUWHS also participates in genome-wide association studies of pancreatic cancer, NHL, and glioma. Finally, the NYUWHS has been funded to conduct studies on cardiovascular disease and the NYUWHS data have motivated the development of new statistical methods. The objectives of this application are to maintain and enhance the infrastructure of the study. The specific aims are to: 1) continue cancer case ascertainment through both active and passive follow-up; 2) update exposure data, including diet and outdoor walking, through follow- up questionnaires; 3) collect tumor blocks for major cancer sites (breast, colorectal, endometrial, and lung) in order to assess risk factors according to molecular subtypes; 4) collect and validate data on neighborhood walkability. The continued follow-up is expected to identify an additional 1,389 cancer cases and the collection of tumor blocks will enhance the value of the study, as will the collection of data on neighborhood walkability. The NYUWHS has several specific strengths. First, serum collected at enrollment and DNA are available for all participants, making the biorepository a valuable resource to study associations between genetic variation, biomarkers, and disease risk. Second, repeat serum samples are available for over half of the participants and are very valuable to assess and improve temporal reliability of circulating markers. Third, while several large cancer cohorts started enrollment at age 50, 6,659 NYUWHS participants were <50 years of age at enrollment/blood donation, providing opportunities for the study of cancer risk factors among younger women. Finally, New York City is a particularly well-suited location for studies of walkability because there is a wide range in walkability across different neighborhoods.