ShEEP-IC: Request for 31 Phosphorus Spectroscopy Imaging System

退伍军人事务部致力于为那些有 在军队服役，研究和发展办公室有责任 了解疾病的基本机制，需要医疗条件的临床表现， 治疗和改善卫生服务提供。此应用程序请求支持共享设备 为研究人员提供关键的基础设施，以通过以下每一项来改善退伍军人的健康 调查路线。普罗维登斯VA医疗中心的研究团体有着悠久的历史， 卓越从心血管疾病的生物学基础， 精神病理学，长期服务创新中心，杰出的康复工作 对于精神和身体疾病，普罗维登斯VAMC在以下领域取得了巨大的成效： 以退伍军人为中心的医学研究。与这一卓越历史相一致的是对尖端技术的要求。 研究基础设施，以服务于这个富有成效的研究社区。因此，本申请要求 支持一件科学仪器，可以扩大许多VA的影响和创新 研究人员 我们正在寻求支持的仪器是一个31磷光谱线圈，以增强我们的 当前的磁共振成像（MRI）能力。具体来说，这种设备允许非侵入性， 研究体内代谢的非辐射暴露技术。31-磷光谱学 利用来自细胞核的磁共振信号提供全面的代谢和生化信息 各种各样的身体组织。这种方法是高度通用的，可以提供代谢的见解的作用， 代谢（特别是能量学）在许多情况下，包括高血压，瓣膜， 缺血性心脏病、外周肌肉变性、神经肌肉疾病、认知/脑 疾病和恶性肿瘤。该方法还可用于监测患者对治疗药物的反应。 干预：药物、手术或干预。当与磁共振成像结合时， 光谱学使得能够详细地了解结构，功能， 灌注和代谢。 获得这种新设备将补充我们目前的MRI研究基础设施， 服务过无数老兵将受益于31-磷光谱学的研究的例子包括Dr. Siddique Abbasi在糖尿病和肥胖相关心肌病方面的工作，我自己在心脏康复方面的工作， 博士Noah Philip在创伤后应激障碍和压力相关认知状态方面的工作，Sharon Round博士在肺 高血压，以及许多其他未成年人用户调查退伍军人健康的关键条件。

The Department of Veteran Affairs is committed to providing cutting-edge medical care to those who have served their country in the Armed Services, and the Office of Research and Development has a responsibility to understand the basic mechanisms of disease, the clinical manifestations of conditions requiring medical treatment, and improvement of health service delivery. This application requests support for shared equipment that provides critical infrastructure to researchers seeking to improve Veteran health through each of those lines of investigation. The research community at the Providence VA Medical Center has a long history of excellence. From the biological bases of cardiovascular disease, to the careful characterization of psychopathology, to the Center of Innovation for Long Term Services, to the outstanding Rehabilitation work for mental and physical disorders the Providence VAMC has been enormously productive in the area of Veteran-centric medical research. Consistent with this history of excellence is the requirement for cutting edge research infrastructure to serve this productive research community. Accordingly, this application requests support for a piece of scientific instrumentation that may extend the impact and innovation of numerous VA researchers. The instrument that we are seeking support for is a 31-Phosphorus spectroscopy coil to enhance our current magnetic resonance imaging (MRI) capabilities. Specifically, this equipment allows for a non-invasive, non-radiation exposing technique for the investigation of metabolism in vivo. 31-Phosphorus spectroscopy uses magnetic resonance signals from nuclei to provide comprehensive metabolic and biochemical information about a variety of bodily tissues. This method is highly versatile and can provide metabolic insights into the role of metabolism (in particular, energetics) in a wide number of conditions, including hypertensive, valvular, and ischemic heart disease, peripheral muscular degeneration, neuromuscular disorders, cognitive/cerebral disease, and malignancy. This method can also be used to monitor patient responses to therapeutic interventions: pharmacologic, surgical, or interventional. When combined with magnetic resonance imaging, spectroscopy enables detailed pathophysiologic insights into the inter-relations among structure, function, perfusion, and metabolism. Obtaining this new equipment will complement our current MRI research infrastructure that has already served countless Veterans. Examples of studies that will benefit from 31-Phosphorus spectroscopy include Dr. Siddique Abbasi’s work in diabetes and obesity-related cardiomyopathy, my own work in cardiac rehabilitation, Dr. Noah Philip’s work in PTSD and stress-related cognitive states, Dr. Sharon Round’s work in pulmonary hypertension, and numerous other minor users investigating conditions critical for Veteran health.