Synthetic DNA & Novel Env Vaccine for HIV

 描述(申请人提供)：该计划的目标是生产一种增强型E/P递送的基因佐剂DNA疫苗(E-DNA)，并将其与高度新颖的多价A、B、C、A/E重组蛋白Boost(PPB)相结合作为疫苗平台。这一应用的EP重点是利用新的表面传递。通过这种组合，我们假设我们将产生比目前的HIV疫苗模式更好的T和B抗HIV免疫反应谱。这个项目建立在这个团队成员的重大创新和成就的基础上，这些创新和成就导致了这项提议。该团队多年来一直在一起卓有成效地合作。此外，他们在与HVTN合作方面有着出色的生产力记录。将CHAVI研究人员纳入临床前开发免疫分析是该计划的一大优势。有三个高度相关、专注于翻译、特别新颖的项目，它们共同建立在强大的成就记录基础上，共同构成了这个项目。它们得到了备受尊敬和关键的蛋白质核心以及经验丰富的管理核心的支持。

 DESCRIPTION (provided by applicant): The goal of this program to produce an enhanced E/P delivered gene adjuvanted DNA vaccine (E-DNA) and combine this with a highly novel polyvalent A, B, C, A/E recombinant protein boost (PPB) as a vaccine platform. The EP focus of this application is to utilize novel surface delivery. By this combination we hypothesize that we will generate an improved spectrum of T and B anti HIV immune responses compared to current HIV vaccine modalities. This project builds on a major innovations and accomplishments by the members of this team that have led to this proposal. The team has worked together productively for multiple years. Furthermore they have an outstanding track record of productivity working with the HVTN. The inclusion of CHAVI investigators as part of the preclinical development immune analysis is a major strength of the program. There are 3 highly interrelated, translational focused, exceptionally novel projects which build on a strong track record of accomplishment together that comprise this program. They are supported by a highly respected and critical protein core as well as seasoned administrative core.