Multi-Scale Electronic Human Brain Atlas

描述(申请人提供)：在这项申请中，我们建议开发一种多尺度、多模式的人脑图谱。该图谱将整合现代活体磁共振成像、体外高分辨率磁共振成像和连续组织学切片获得的不同空间分辨率的数据，覆盖范围从1毫米到小于1毫米。健康受试者的全脑活体MRI将提供全球坐标系，所有较高分辨率的数据都将被记录到该坐标系中，将同一坐标系下不同尺度的解剖信息连接起来。这本图集将作为一个信息技术基础设施，整合和传播来自不同来源、不同规模的大量基于文本和图像的大脑解剖知识，如临床核磁共振病例和组织切片。这些内容将在多比例地图集中有机地联系在一起，为组织、管理、呈现和使用我们以及用户提供的数据提供一个独特的环境。我们希望多尺度、多模式的大脑图谱将极大地增强我们组织、管理、展示和利用我们关于大脑的知识的能力。我们相信我们有独特的资源和记录来为这项有希望的努力做出贡献；我们已经推出了第一批人脑3D电子地图集之一。我们的大脑图谱已经被采纳为大脑解剖学的标准研究工具之一，在过去的1000多份出版物中做出了贡献。我们的基于云的图像分析服务现在支持全球超过7,000名注册研究人员。在这项提案中，我们将通过以下目标扩展我们过去的努力，建立一个新的脑研究、教育和临床支持的信息学平台；目标1：收集基于体内和体外MRI和组织学的多尺度、多模式的人脑成像数据目标2：建立多尺度图谱内容目标3：建立多尺度图谱界面目标4：测试基于云的信息链接到图谱标签和坐标

DESCRIPTION (provided by applicant): In this application, we propose to develop a multi-scale, multi-modal human brain atlas. The atlas will integrate data with different spatial resolution acquired by modern in vivo MRI, ex vivo high-resolution MRI, and serial histology sections, covering 1 mm scale to less than 1mm. The whole-brain in vivo MRI of healthy subjects will provide the global coordinate system, to which all higher-resolution data will be registered, connecting anatomical information with different scales under the same coordinate system. This atlas will serve as an IT infrastructure to integrate and disseminate a large amount of text and image-based anatomical knowledge of the brain from different sources at different scales such as clinical MRI cases and histology sections. These contents will be organically related in the multi-scale atlas, providing a unique environment to organize, manage, present, and use the data provided by us as well as by users. We expect the multi-scale, multi-modal brain atlas will hugely enhance our ability to organize, manage, present, and utilize our knowledge about the brain. We believe we have unique resources and track-records to contribute to this promising endeavor; we have introduced one of the first 3D electronic atlases of the human brain. Our brain atlases have been adopted as one of the standard research tools for brain anatomy, contributed to more than 1,000 publications in the past. Our cloud-based image analysis service now supports more than 7,000 registered researchers worldwide. In this proposal, we will extend our past effort and establish a novel informatics platform for brain research, education, and clinical support through the following aims; Aim 1: To collect multi-scale, multi-modal human brain imaging data based on in vivo and ex vivo MRI and histology Aim 2: To build multi-scale atlas contents Aim 3: To build the multi-scale atlas interface Aim 4: To test the cloud-based information link to the atlas labels and coordinates