Validating an automated nephrolithiasis registry as a community research tool

总结/摘要：管理核心 我们的研究计划的总体目标是开发一个自动化的，集成的临床注册， 资源支持多机构，高影响力的研究在泌尿外科界。加州大学旧金山分校一直是 过去曾获得P20中心科学项目赠款以支持肾结石研究。目前中心 由马歇尔·斯托勒博士指导的项目已经进入了最后一年的资助期。该中心的中心主题是审查 小分子、金属和结石发病机制之间的联系。目前的P20提案是一种资源 开发项目，并独立于先前授予的 中心它具有鲜明的资源开发重点，独立的领导和独立的科学 方向鉴于结石形成的多因素原因以及与多种疾病的相关性， 包括肥胖和炎症，迫切需要一种跨学科的方法来研究结石。 疾病我们已经召集了一批研究人员和合作中心，他们在广泛的 学科范围。在过去的4年里，研究小组的核心成员定期开会，至少 一个月两次，讨论研究工作;一个活动，我们已经准备好创建一个 资源开发的跨学科中心。这些会议创造了独特的协同作用， 小组的各个成员，我们有很好的定位，使发现，将有重大影响， 肾结石领域。为了验证拟议的资源开发项目，5个合作中心 将参与注册表的实施和验证。行政核心将负责 整合我们的多个合作站点，并通过创造机会促进跨学科方法 与来自多个研究中心的研究者进行定期报告和讨论。我们将努力发展 通过我们的出版物，与更广泛的研究界加强互动，国家和国际 会议，我们的系列讲座和年度研讨会。这将通过三个目标来实现：1。整合 支持结石病研究的跨学科观点，2.确保有效管理 中心内的资源，以及3。拓展和发展与更广泛研究的互动 社区我们将参与教育推广，欢迎来自世界各地的访问教授和科学家。 其他机构。对于UCSF P20资源开发中心，将开发一个互动网站， 定期更新。总之，这些努力将有助于创建一个独特的，独一无二的，P20中心， 结石病提供了一个研究资源，以刺激未来的研究人员在开拓新的领域， 研究和提高公众对研究益处的认识。

SUMMARY/ABSTRACT: ADMINISTRATIVE CORE The overall goal of our research program is to develop an automated, integrated clinical registry as new resource supporting multi-institutional, high impact research within the urologic community. UCSF has been awarded P20 Center Scientific Project Grants to support nephrolithiasis research in the past. Its current Center is in its last year of funding, directed by Dr. Marshall Stoller. The central theme of that Center is to examine the link between small molecules, metals, and stone pathogenesis. The current P20 proposal is a Resource Development Project and was developed independently of activity sponsored by the previously awarded Center. It features a distinct resource development focus, separate leadership, and an independent scientific direction. Given the multifactorial causes for formation of stones and the association with multiple conditions including obesity and inflammation, there is an urgent need for an interdisciplinary approach to studying stone disease. We have assembled a group of researchers and collaborating centers with proven expertise in a wide range of disciplines. For the last 4 years, the core members of the research team have met regularly, at least twice a month, to discuss the research effort; an activity which has prepared us well to create an interdisciplinary center for a resource development. These meetings have created unique synergies between various members of the group and we are well positioned to make discoveries that will have a major impact on the field of nephrolithiasis. To validate the proposed Resource Development Project, 5 collaborating centers will participate in registry implementation and validation. The Administrative Core will be responsible for integrating our multiple collaborating sites and fostering an interdisciplinary approach by creating opportunities for regular presentations and discussions with investigators from multiple sites. We will strive to develop stronger interactions with the wider research community through our publications, national and international conferences, our lecture series and annual symposia. This will be accomplished by three aims: 1. Integrating interdisciplinary viewpoints to support stone disease research, 2. Ensuring efficient management of resources within the center, and 3. Outreach and developing interactions with the wider research community. We will be involved in educational outreach, embracing visiting professors and scientists from other institutes. For the UCSF P20 Resource Development Center an interactive website will be developed and updated on a regular basis. Together, these efforts will help create a unique, one of a kind, P20 center for stone disease providing a research resource to stimulate future investigators in pioneering novel areas of research and increased public awareness of the benefits of research.