CPS-Cancer Prevention & Survivorship Research Program

癌症预防和生存--项目摘要 癌症预防和生存(CPS)侧重于癌前生物学及其在早期的翻译 测试新的预防战略以及旨在改善癌症生活质量的干预措施 幸存者。在癌前生物学和风险生物标记物主题中，研究中心是组织变化， 作为恶变的指标或预测指标，以及开发新的潜在目标 预防策略。在预防和生存翻译研究主题中，来自 癌前生物学和风险生物标记物主题与行为和临床研究人员合作 新战略的测试。CPS与癌症控制和人口控制(CCPH)的独特之处在于 重点关注新生物标记物的发现和预防和生存的早期测试 使用高危人群的干预措施，而社区卫生保健侧重于实施已知有效的 战略。CPS有21名正式成员和10名准成员，他们来自16个部门/部门，具有癌症方面的专业知识 生物学、内外科肿瘤学、放射生物学、胃肠病学、护理学、临床健康心理学 营养学、运动生理学和生物医学信息学。2015年，CPS增加了NCI(12个)和 自2011年(CCSG提交的上一份文件)以来，经同行审查的赠款总额(29笔)来自6笔和24笔赠款。其中七个 同行评审的赠款是多个PI奖项，而不是一个。NCI和同行评审资金总额增加 从1,804,303美元和6,244,484美元增加到3,098,479美元和11,890,377美元。从2012到2015年，超过800名患者 共进行了15次干预试验。这些试验中有12项是由研究者发起的，3项是同行评审的 有资金支持。堪萨斯州和密苏里州的成年人肥胖率很高。因此，许多CPS介入试验 与集水区合作伙伴密切合作，专注于体力活动和减肥。CPS 自2012年以来，成员发表了382篇文章，其中164篇(43%)是计划内文章，127篇(33%)是计划内文章 有204人(54%)进行了机构间合作。45份出版物(12%)有 期刊影响因素≥8。CPS为韩国大学做出了重要的领导贡献(董事和三位广告，主席 PRMC，SWOG生存委员会联合主席)和基于高度翻译的生物标记物的早期阶段 预防和生存试验通常与平行的动物研究相结合。SWOG椅子位置有助于移动 有希望的飞行员将参加更大规模的合作小组试验。KUCC通过共享资源为CPS做出贡献 和试点资金。在未来，CPS将继续加强其新的癌前模型、新的 风险和反应生物标记物、早期试验的高风险队列、能量平衡和天然产品 化学预防试验。CPS将加强与CB的合作，以扩大生物标志物研究 代谢组学，用D3ET开发初级预防的天然产品类似物，用CCPH开发 扩大差距和集水区相关研究，以及教育倡议和指导。

Cancer Prevention and Survivorship – Project Summary Cancer Prevention and Survivorship (CPS) focuses on pre-cancerous biology and its translation into initial testing of new prevention strategies, as well as interventions aimed at improving the quality of life for cancer survivors. In the Pre-Cancerous Biology and Risk Biomarkers theme, research centers on tissue changes that serve as indicators or predictors of malignant transformation and potential targets for developing new preventive strategies. In the Prevention and Survivorship Translational Research theme, basic scientists from the Pre-Cancerous Biology and Risk Biomarkers theme work with behavioral and clinical researchers for early testing of new strategies. CPS is unique from Cancer Control and Population Control (CCPH) in that CPS focuses on the discovery of new biomarkers and early phase testing of prevention and survivorship interventions using high-risk individuals, whereas CCPH focuses on implementation of known effective strategies. CPS has 21 full and 10 associate members from 16 departments/divisions with expertise in cancer biology, medical and surgical oncology, radiation biology, gastroenterology, nursing, clinical health psychology, nutrition, exercise physiology and biomedical informatics. In 2015, CPS increased the number of NCI (12) and total peer-reviewed (29) funded grants from 6 and 24 since 2011, the previous CCSG submission. Seven of the peer-reviewed grants are multi-PI awards, up from one. NCI and total peer-reviewed funding increased from $1,804,303 and $6,244,484 to $3,098,479 and $11,890,377. From 2012-2015, over 800 patients were accrued to 15 intervention trials. Twelve of these trials were investigator-initiated and three peer-reviewed funded. Kansas and Missouri have high rates of adult obesity. Thus, many of the CPS interventional trials focus on physical activity and weight reduction, in close collaboration with catchment area partners. CPS members have published 382 articles since 2012 of which 164 (43%) had intra-programmatic, 127 (33%) had inter-programmatic and 204 (54%) had inter-institutional collaborations. Forty-five publications (12%) had a journal impact factor ≥ 8. CPS contributes to KUCC with significant leadership (Director and three ADs, Chair PRMC, Co-chair SWOG Survivorship Committee) and highly translational biomarker based early phase prevention and survivorship trials often with parallel animal studies. The SWOG chair position helps move promising pilots into larger co-operative group trials. KUCC contributes to CPS both through shared resources and pilot funding. In the future, CPS will continue to build on its strengths of novel pre-cancerous models, new risk and response biomarkers, high-risk cohorts for early phase trials, energy balance and natural products in chemoprevention trials. CPS will increase collaborations with CB to expand biomarker research in metabolomics, with D3ET to develop natural product analogues for primary prevention and with CCPH to increase disparity and catchment area-relevant research, as well as educational initiatives and mentoring.