Development of hydraulically fractured oil and natural gas sites and incidence of atrial fibrillation claims in Colorado's All Payer Claims Database

项目摘要/摘要 心房颤动(房颤)是最常见和临床意义重大的心律失常，其结果是 生活质量和中风、系统性血栓栓塞症和心力衰竭的风险显著增加。我们的 初步数据表明，居住在HFOG井场附近的人可能会经历血压上升 和动脉僵硬与房颤相关。水力压裂油和天然气的发展 天然气(HFOG或“水力压裂”)井场与两个新出现的环境风险因素房颤、空气和 噪音污染。虽然这一证据表明房颤患者居住在靠近 发展 复杂的是，如果HFOG开发过程中出现的空气和噪声污染很好 房颤的病因和负担与房颤部位有关。我们缺乏必要的初步数据来证明 有效地设计前瞻性研究将是解决了解这些问题的迫切需求所必需的 病因关系。如果没有这些初步数据，我们就无法推进调查方法 与HFOG井址相关的环境风险与AF之间的时间关系。我们的长期目标是 了解与HFOG和房颤相关的环境风险之间的流行病学关系 相关的健康结果。这项提案的总体目标是将科罗拉多州所有付款人的索赔联系起来 数据库(APCD)和科罗拉多州O&G信息系统(COGIS)以获得初步数据 有必要证明综合队列研究的设计是合理的，并为其提供信息。为了达到这一目标，我们将 采用纵向间断时间序列交叉设计，对2500例房颤患者进行回顾性随访。 APCD居住在距离HFOG 830个井点1.6公里(1英里)的范围内，开发于2010至2015年间。我们的 中心假设是房颤和房颤相关发病率的风险在房颤的发展过程中增加。 HFOG Well站点，妇女、老年人和有既往健康状况的人更多 易受影响。我们将确定并比较索赔发生率与房颤和房颤的基本诊断 HFOG井位1.6公里内房颤患者发病前、发病中和发病后的相关死亡率 该网站的。这项拟议的研究将第一次评估HFOG的发展与 井位和房颤相关发病率。我们研究的结果将使我们能够确定队列研究是否 有保证的，如果有保证的，告知此类研究的设计。这项未来的研究将前瞻性地遵循 测量HFOG井位发展过程中房颤和相关发病率的人群 与这一发展相关的特定环境风险因素。考虑到快速增长的数字 对于居住在HFOG井场附近的人来说，我们努力了解 尽快解决相关的健康风险，以便我们能够制定最好的预防和补救措施 那些人。 的HFOG站点可能面临更大的房颤和相关事件的风险 目前尚不清楚

Project Summary/Abstract Atrial fibrillation (AF) is the most common and clinically significant cardiac arrhythmia and results in impaired quality of life and substantially elevated risks for stroke, systemic thromboembolism and heart failure. Our preliminary data indicates that people living near HFOG well sites may experience increases in blood pressure and arterial stiffness that are associated with AF. The development of hydraulically fractured oil and natural gas (HFOG or “fracking”) well sites is associated with two emerging environmental risk factors for AF, air and noise pollution. While this evidence indicates that AF patients who reside in close proximity to the development complications, is if the air and noise pollution that occur during the development of HFOG well sites contribute to the etiology and burden of AF. We lack the preliminary data necessary to justify and efficiently design the prospective study will be necessary to address the pressing need to understand these etiological relationships. Without this preliminary data, we are unable to advance methods to investigate the temporal relationships between environmental risks related to HFOG well sites and AF. Our long-term goal is to understand the epidemiological relationships between environmental risks associated with HFOG and AF related health outcomes. The overall objective for this proposal is to link the Colorado All Payer's Claim Database (APCD) and the Colorado O&G Information system (COGIS) to obtain the preliminary data necessary to justify and inform the design of a comprehensive cohort study. To meet this objective, we will employ a longitudinal interrupted time-series crossover design to retrospectively follow ~ 2500 AF patients in the APCD living within 1.6 kilometers (1-mile) of 830 HFOG well sites developed between 2010 and 2015. Our central hypothesis is that there is an increased risk of AF and AF associated morbidity during development of a HFOG well site to which women, the elderly, and those with pre-existing health conditions are more susceptible. We will determine and compare the incidence of claims with a principle diagnosis of AF and AF related mortality in AF patients living within 1.6 km of a HFOG well site before, during, and after development of the site. The proposed study will be the first to evaluate relationships between the development of HFOG well sites and AF related morbidity. Findings from our study will allow us to determine if a cohort study is warranted and if warranted, inform the design of such a study. This future study would prospectively follow populations for AF and related morbidity over the course of development of HFOG well sites while measuring specific environmental risk factors associated with this development. Considering the rapidly growing number of people living in close proximity to an HFOG well set, it is essential that we work to understand the associated health risks as soon as possible so that we can develop the best preventions and remedies for those people. of HFOG sites may be at a significantly greater risk for additional incidents of AF and associated it is not known