COBRE in CV Health Research Core

项目总结/摘要 心血管健康领域的COBRE汇集了来自多个学科的研究人员，重点关注 心血管健康的血管方面，并将建立一个新的心血管研究核心， 特拉华州大学（UD）。COBRE心血管健康将利用新兴的优势， 心血管研究在UD创建一个新的签名COBRE，和来自多个学科的研究人员， 该中心将研究减少的机制、后果和潜在的干预措施， 心血管健康跨越基础，临床/转化和基于社区的研究到一定程度， 现有的仪器无法支持。因此，该中心将建立一个心血管研究中心， 核心和支持建立特拉华州生物技术研究所（DBI）生物成像核心。这些核心将 为心血管功能和健康评估、生物统计学和生物成像提供资源， 提高子项目研究者以及其他研究者的心血管研究能力。 中心，大学和地区。 心血管研究中心（CVRC）的建立将促进心血管疾病的评估， 在啮齿动物和人类中发挥作用。CVRC将使研究人员能够评估啮齿动物的血管功能， 通过仪器的可用性， 人员专业知识。该核心利用了UD健康科学综合体的新设施， 与UD护士管理健康中心合作。建立、监督和 维修CVRC概述。 我们还将支持和扩展现有的DBI生物成像核心，以促进内皮细胞成像 从人类志愿者以及啮齿动物骨骼中收集的血管。我们将扩大现有的生物成像 中心增加了显微镜载玻片扫描仪和成像仪，用于载玻片的高通量成像， 为生物成像人员提供支持。概述了监督和维护计划。

PROJECT SUMMARY/ABSTRACT The COBRE in Cardiovascular Health brings together investigators from multiple disciplines focused on vascular aspects of cardiovascular health and will establish a new Cardiovascular Research Core at the University of Delaware (UD). The COBRE in Cardiovascular Health will capitalize on an emerging strength in cardiovascular research at UD creating a new signature COBRE, and researchers from multiple disciplines in the center will investigate the mechanisms, consequences, and potential interventions for declining cardiovascular health spanning basic, clinical/translational, and community based research to a degree that cannot be supported by existing instrumentation. Thus, this center will establish a Cardiovascular Research Core and support the established Delaware Biotechnology Institute (DBI) Bio-Imaging Core. These cores will provide resources for assessment of cardiovascular function and health, biostatistics, and bioimaging that will enhance cardiovascular research capabilities of the subproject investigators, as well other investigators in the center, university, and region. This establishment of a Cardiovascular Research Core (CVRC) will facilitate the assessment of cardiovascular function in rodents and humans. The CVRC will enable researchers to assess vascular function in rodents and humans, and ambulatory and central blood pressure in humans through the availability of instrumentation and personnel expertise. This core takes advantage of new facilities in the UD Health Sciences Complex and collaboration with the UD Nurse Managed Health Center. A plan for the establishment, oversight and maintenance of the CVRC is outlined. We will also support and expand existing DBI Bio-Imaging Core to facilitate the imaging of endothelial cells collected from human volunteers as well as vessels from rodent bone. We will expand the existing Bio-Imaging Center with the addition of a microscope slide scanner and imager for high throughput imaging of slides and provide support for Bio-Imaging personnel. A plan for oversight and maintenance is outlined.