FASEB SRC on Calpains in Health and Disease

项目总结： 正在征求这份R13提案，以提供对以下方面的FASEB夏季研究会议的部分支持 《钙调蛋白在健康和疾病中的生物学》。这次会议已经成为卡尔佩恩的重要手段 来自不同学科的研究人员会面并交流未发表的数据和专业知识。通过这些 会议(每三年举行一次)，专注于Calain的研究人员之间富有成效的合作， 促进了临床医生和行业的发展，因为 FASE B SRC场馆。会议为信息交流提供了一个具有智力吸引力的论坛 在出版之前，它让教员和他们的实习生了解新兴研究和 稀有资源和试剂的可用性。这些机会有效地增加了人们对钙蛋白酶的兴趣 研究，吸引年轻的研究人员，推动新的发现。钙调蛋白由一大类蛋白水解酶组成。 它们在物种之间非常保守，在组织中无处不在地分布。因为他们的 自发现以来，对它们的多样性、结构、生理作用的了解已经取得了显著的进展 以及与疾病的关系。今天，有7000多篇研究文章聚焦于钙调痛症。因为 钙调蛋白与神经退行性变、肌肉和代谢性疾病等疾病的相关性日益增强， 伤口愈合、胃肠道疾病、炎症和癌症，这个领域正在不断扩大。 在NIH、国防部和NSF之间，联邦政府每年在这方面的投资超过3300万美元 研究领域-资助90多个涉及钙蛋白酶的项目。会议正在联合举行。 主办单位：加州大学洛杉矶分校的Melissa Spencer和辛辛那提儿童基金会的Leah Kottyan 医院医疗中心。会议咨询委员会成员包括：Vinit Mahajan，Stanford，Athar Chishti， 塔夫茨大学，多萝西·克罗尔，缅因州大学，吉姆·盖德斯，肯塔基大学，彼得·格里尔，皇后区 加拿大大学和佛罗里达大学的凯文·王。这次由FASEB组织的会议是主要的 世界各地的Calain研究人员有机会收集和交换未发表的数据，并 协同研究项目和想法。因此，这次会议充分利用了NIH的投资，并催化了 这一领域的进步。

PROJECT SUMMARY: This R13 proposal is being solicited to provide partial support for a FASEB Summer Research Conference on “The Biology of Calpains in Health and Disease”. This conference has become a vital means for calpain researchers from different disciplines to meet and exchange unpublished data and expertise. Through these conferences (that occur every third year), productive collaboration between calpain-focused investigators, clinicians and industry has been facilitated, due to increased interaction and exposure that is fostered by the FASEB SRC venues. The meeting has provided an intellectually engaging forum for information exchange prior to publication and has allowed faculty and their trainees to learn about emerging research and the availability of rare resources and reagents. These opportunities effectively increase the interest in calpain research, attract young investigators and propel new discovery. Calpains comprise a large family of proteases that are tremendously conserved amongst species and are ubiquitously distributed in tissues. Since their discovery, there has been remarkable progress in understanding their diversity, structure, physiological roles and involvement in diseases. Today, more than 7,000 research articles focus on the calpains. Because of the increasing relevance of calpains to diseases such as neurodegeneration, muscle and metabolic diseases, wound healing, gastrointestinal disease, inflammation, and cancer, the field is continuously expanding. Between the NIH, the DOD and NSF, the federal government invests more than $33 mil per year in this research area–funding more than 90 projects involving calpain proteases. The meeting is being co- organized by: Melissa Spencer, University of California Los Angeles, and Leah Kottyan, Cincinnati Children’s Hospital Medical Center. Meeting Advisory Committee includes: Vinit Mahajan, Stanford, Athar Chishti, Tufts University, Dorothy Croall, University of Maine, Jim Geddes, University of Kentucky, Peter Greer, Queens University, Canada, and Kevin Wang, University of Florida. This FASEB-organized meeting is the primary opportunity for calpain researchers around the world to gather and exchange unpublished data and to synergize research projects and ideas. Thus, this meeting leverages NIH’s investment and catalyzes progress in the field.