Coordination Center for Open Collaboration in Systems Biology

摘要 作为一家非营利性研究机构，Sage Bionetworks的动力来自于我们的科学所能创造的影响， 无论是直接还是与合作者。我们已经创建了开放的生物信息学和数据资源， 我们参与的大型研究项目，涵盖了涉及临床， 与肿瘤学研究相关的成像、组学和移动的传感器数据。在过去的四年里，我们 开发了Synapse，这是一个托管科学数据、代码和知识的信息学平台， 建立了与大型研究财团进行有效互动的出色记录。 我们已经通过支持需要数十到数百个的研究工作来测试Synapse平台。 科学家可以真实的实时共享数据、分析代码和结果。这个平台，以及Sage的数据活动 科学家和策展人，形成了资源协调中心的基础。这些努力提供了一个模式， 我们与协作和试点项目中心的其他CSBC和PS-ON中心的互动。之一 我们最成功的形成和参与研究社区的策略是组织和运行 名为梦想挑战的众包竞赛将成为外联中心的核心。

Abstract As a non-profit research institution, Sage Bionetworks is driven by the impact that our science can create, either directly, or with collaborators. We have created open bioinformatics and data resources as part of every large-scale research project in which we have participated, covering a diverse set of projects involving clinical, imaging, `omics, and mobile sensor data related to research in oncology. Over the past 4 years, we have developed Synapse, an informatics platform for hosting scientific data, code, and knowledge, and have established an outstanding track record of effective interactions that engage large scale research consortia. We have tested the Synapse platform by supporting research efforts that required dozens to hundreds of scientists to share data, analysis code, and results in real time. This platform, and the activities of Sage's data scientists and curators, form the basis for the Resource Coordinating Hub. These efforts provide a model for our interactions with the other CSBC and PS-ON centers in the Collaboration and Pilot Project Hub. One of our most successful strategies for forming and engaging research communities has been to organize and run crowdsourced competitions called DREAM Challenges will form the core of the Outreach Hub.