Training Program in Free Radical and Radiation Biology

 描述（由申请人提供）：爱荷华州大学放射肿瘤学的自由基和放射生物学培训计划旨在提供跨学科的研究生和研究生培训，重点是为生物医学研究和教育中癌症相关领域的职业培训学员的六个关键教育目标：1）传授辐射生物学，自由基生物学和癌症生物学的主题的基本理解; 2）为学员提供机会，以达到熟练的实验辐射生物学，自由基生物学，和分子肿瘤学学科导致成功的职业生涯中的癌症研究3）结构的研究经验，包括研究计划的发展，研究项目的执行，并提交给同行评审的期刊的科学结果的评估学员; 4）为学员提供学习技能的经验，这些技能是与临床和基础科学部门的教师进行合作研究所必需的，以将自由基和辐射生物学的基本机械知识从实验室翻译到床边; 5）为学员提供必要的批判性思维和技能，以有效地沟通科学知识，在口头和书面陈述他们的研究; 6）鼓励学员在“真实的世界”环境中实施创新方法，使用假设驱动的研究技术，放射生物学和氧化还原生物学现象的基本机制，因为它们与癌症生物学相关，重点是开发新型干预措施以限制癌症对健康的影响。 我们建议每年资助三名博士前和三名博士后学员。我们拥有国际公认的教师，在放射生物学和自由基癌症生物学研究人员发起的研究奖项以及出版物方面取得了一致的成功记录。我们建议有13个资金充足和专门的计划教师（包括初级和高级教师队伍），拥抱一个多元化的知识体系，协同包括自由基和辐射生物学在爱荷华州大学的跨学科计划。13个项目的教职员工包括7名教授，3名副教授和3名助理教授，其中4名来自放射肿瘤学，3名来自内科，2名来自生物化学，1名来自病理学，精神病学/神经病学，放射学和外科。学员的教育活动包括教师的一对一指导，癌症相关的国家认可的研究项目，在全国会议上展示工作并接受反馈，2个期刊俱乐部/周，1个研讨会/周，1个翻译研究会议/周，以及在该计划中最先进的核心实验室资源的技术培训。正规研究生水平 由教师提供的课程（需要预博士）包括辐射，自由基和癌症生物学课程以及医学物理学课程，重点是图像引导的癌症治疗。跨学科的癌症相关研究正在由教师追求跨越从基础机制研究到转化临床前以及临床研究的广泛范围。该计划有50多年的历史，培养了从事癌症研究和自由基生物学的杰出科学家。

 DESCRIPTION (provided by applicant): The Free Radical and Radiation Biology Training Program in Radiation Oncology at the University of Iowa was established to provide interdisciplinary graduate and post-graduate training with a focus on six key goals for education in preparation of trainees for careers in cancer-related fields within biomedical research and education: 1)To impart a fundamental understanding of the subject matter of radiation biology, free radical biology, and cancer biology; 2) To provide trainees with the opportunity to achieve proficiency in the experimental radiation biology, free radical biology, and molecular oncology disciplines leading to successful careers in cancer research; 3) To structure research experiences for trainees that include the development of a research proposal, execution of a research project, and evaluation of scientific results for submission to peer- reviewed journals; 4) To offer trainees experiences in learning skills necessary to do collaborative research with faculty in both clinical and basic science departments to translate fundamental mechanistic knowledge in free radical and radiation biology from the bench-to-bedside; 5) To provide trainees with the critical thinking and skills necessary to effectively communicate scientific knowledge in both oral and written presentations of their research; and 6) To encourage trainees to implement innovative approaches in a "real world" environment to test, using hypothesis driven research techniques, the basic mechanisms underlying radiobiological and redox biology phenomena as they relate to cancer biology with an emphasis on developing novel interventions to limit the health related impact of cancer. We are proposing to support three predoctoral and three postdoctoral trainees per year. We have an internationally recognized faculty with a consistent track record of success in radiobiology and free radical cancer biology investigator initiated research awards as well as publications. We propose to have 13 well- funded and dedicated program faculty members (both junior and senior faculty ranks) that embrace a diverse body of knowledge that synergistically comprises the interdisciplinary program in Free Radical and Radiation Biology at the University of Iowa. The 13 program faculty members consist of 7 Professors, 3 Associate Professors, and 3 Assistant Professors of which 4 are from Radiation Oncology, 3 from Internal Medicine, 2 from Biochemistry, and 1 each from Pathology, Psychiatry/Neurology, Radiology, and Surgery. Educational activities for trainees includes one-on-one mentoring by faculty, cancer-related nationally recognized research projects, presenting work and receiving feedback at national meetings, 2 journal clubs/week, 1 seminar/week, 1 translational research meeting/week, and technical training in the state of-the-art core lab resources in the program. Formal graduate level coursework offered by the faculty (required for pre-docs) includes classes in radiation, free radical, and cancer biology as well as a course in medical physics with an emphasis on image guided cancer therapy. The interdisciplinary cancer related research being pursued by the faculty spans a wide spectrum from basic mechanistic studies to translational preclinical as well as clinical studies. The program has a 50+ year history of producing outstanding scientists working in cancer research and free radical biology.