2019 Neurotrophic Mechanisms in Health and Disease Gordon Research Conference

摘要 这项提议是为了支持初级研究员、博士后研究员和学生参加 戈登研究会议(GRC)关于健康和疾病中的神经营养机制。会议将于 将于2019年6月2日至7日在RI新港的Salve Regina大学举行。神经营养因子，广义定义为 在电路连通性、突触可塑性和行为中起关键作用的因素对于 神经系统的发育、维持和功能。重要的是，几种利用 神经营养素生物学的知识目前正在进行慢性疼痛、阿尔茨海默病和 癌症。因此，基础研究人员和临床医生的不同社区解决了源于神经营养因子的问题 生物学。 2019年健康和疾病中的神经营养机制GRC是独一无二的，它汇集了多种 跨分子和细胞基本问题领域的研究人员的学科小组 神经科学将神经营养素生物学转化为疗法。这次会议将提供一个独特的场所， 将神经营养因子生物学的基础研究与临床需求和行业兴趣相结合，最终 加速开发和采用治疗人类神经疾病的新疗法的目标， 精神疾病，以及某些形式的癌症。这次会议将把演讲者聚集在一起，许多人都是新来的 会议，谁将向神经营养因子生物学与电路形成、学习和记忆的交叉点发表讲话， 抑郁症、慢性疼痛、癌症、阿尔茨海默病和慢性炎症。其他主题和后期- 突破性的发展将通过从摘要中挑选出来的演讲纳入，特别是鼓舞人心的演讲 初级研究人员的参与。 几个新功能将2019年GRC神经营养因子会议与以前的会议区分开来。 其中包括强调神经营养因子生物学与系统方法和治疗方法的交叉。 途径，招聘一批新加入我们会议的初级调查人员，他们将向新兴领域发言 并将提供新的观点，为初级实习生引入教师指导系统，并提供 有利于家庭的政策，如现场儿童保育和补贴，以抵消儿童保育/住宿费用。

Abstract This proposal is to provide support for junior investigators, post-doctoral fellows, and students to attend the Gordon Research Conference (GRC) on Neurotrophic Mechanisms in Health and Disease. The meeting will be held in Salve Regina University, Newport RI from June 2-7, 2019. Neurotrophic factors, broadly defined as factors that have critical roles in circuit connectivity, synaptic plasticity, and behavior, are essential for the development, maintenance, and functions of the nervous system. Importantly, several treatments that exploit knowledge of neurotrophin biology are now in human clinical trials for chronic pain, Alzheimer’s disease, and cancer. Thus, diverse communities of basic researchers and clinicians address problems rooted in neurotrophin biology. The 2019 Neurotrophic Mechanisms in Health and Disease GRC is unique in bringing together a multi- disciplinary group of researchers in areas spanning fundamental problems in molecular and cellular neuroscience to translating neurotrophin biology into therapies. This meeting will provide a unique venue to integrate basic research on neurotrophic factor biology with clinical needs and industry interest, with the ultimate goal of accelerating the development and adoption of new treatments for human neurological conditions, psychiatric diseases, and some forms of cancers. The conference will bring together speakers, many new to the meeting, who will speak to the intersection of neurotrophin biology with circuit formation, learning and memory, depression, chronic pain, cancer, Alzheimer’s disease and chronic inflammation. Additional topics and late- breaking developments will be incorporated via talks selected from abstracts, specifically encouraging participation of junior researchers. Several new features distinguish the 2019 GRC Neurotrophic Factor conference from earlier meetings. These include an emphasis on the intersection of neurotrophin biology with systems approaches and therapeutic avenues, recruitment of a cohort of junior investigators new to our meeting who will speak to emerging areas and will provide fresh perspectives, introduction of a faculty mentoring system for junior trainees, and offering family friendly policies such as on-site child-care and subsidies to offset costs of childcare/accommodation.