Nicaraguan Emerging and Endemic Diseases (NEED) Training Program

联系PD/PI：Becker-Dreps，Sylvia 摘要 不 新出现的病毒性疾病和地方性病毒性疾病对全球的影响越来越大，这是一个关键的公共卫生问题。爆炸 2015年，寨卡病毒在整个拉丁美洲和加勒比地区传播， 基孔肯雅病毒的传播模式2017年，来自亚马逊地区的黄热病病毒在里约热内卢出现 里约热内卢，强调了大城市爆发的风险。除了这些新出现和重新出现的病毒， 地方性病毒继续造成很高的疾病负担。杯状病毒现在是导致 尼加拉瓜儿童腹泻、流感和呼吸道合胞病毒继续造成高负担， 目前，所有四种登革热血清型都是地方性的。我们设计了一个程序来训练 尼加拉瓜的创新科学家骨干，以应对这些高度优先的新出现的地方病病原体， LMIC机构。这一计划的基本原理是通过增加人口， 当地科学家的数量和专业知识，以1）描述这些病毒病原体的流行病学，2）了解 其对发病率和死亡率的影响，以及3）确定循证方法，以降低其流行率 和疾病负担。四川省新发和地方病（NEED）培训计划 国立自治大学之间的长期关系的融合的优势 尼加拉瓜、莱昂（UNAN-León）和北卡罗来纳州查佩尔山大学（莱昂），现有的合作项目 培训生项目研究和强有力的双边机构支持。该方案的目标包括：1） 为两名年轻的传染病流行病学博士生提供长期的培训。 来自UNAN-León的调查人员。这些毕业生将为UNAN-León的核心研究人员做出贡献， 解决紧迫的地方研究议程; 2）创造训练有素的生物医学可持续供应 科学家在该地区建立一个认可的博士学位课程在生物医学科学在UNAN- 莱昂;我们将在初始队列中招收五名博士前候选人。该计划建立在一个成功的 微生物学硕士课程在UNAN-León到位，并填补了尼加拉瓜对严格的博士学位的巨大需求， 水平的生物医学研究培训。我们进一步支持这些博士前学员为期一个月的五个 实验室培训，3)在140名学生中促进专业成长和研究技能发展 各级学员，包括当地教师，以确保学术和研究的成功。稳健的短期 培训专业和研究技能需要成为一个独立的调查员和成功的 为学员和当地教师提供院士，以确保该计划的影响更大 大致上该计划将在UNAN-Leon建立一个多学科研究团队，以应对新兴的 以及影响区域和全球公共卫生的地方性病毒性疾病。我们的方法是可行的 通过利用UNAN-León现有的成功硕士课程，并为学员提供机会 与导师在两个合作研究项目的不断增长的一系列合作伙伴在布宜诺斯艾利斯和UNAN-León。

Contact PD/PI: Becker-Dreps, Sylvia Abstract t The growing, global impact of emerging and endemic viral diseases is a critical public health issue. The explosive spread of zika virus throughout Latin America and the Caribbean in 2015 followed only two years after a similar pattern of spread of chikungunya virus. In 2017, yellow fever virus from Amazon regions emerged in Rio de Janeiro, underscoring the risk of a major urban outbreak. In addition to these emerging and reemerging viruses, endemic viruses continue to cause a high burden of disease. Caliciviruses are now the leading causes of childhood diarrhea in Nicaragua, influenza and respiratory syncytial virus continue to cause a high burden of respiratory disease, and all four dengue serotypes are now endemic. We have designed a program to train a cadre of innovative scientists in Nicaragua to confront these emerging and endemic pathogens of high priority to the LMIC institution. The rationale for this program is to protect the public health of populations by increasing the numbers and expertise of local scientists to 1) describe the epidemiology of these viral pathogens, 2) understand their impact on morbidity and mortality, and 3) identify evidence-based approaches to reduce their prevalence and burden of disease. The Nicaraguan Emerging and Endemic Diseases (NEED) Training Program takes advantage of the convergence of a longstanding relationship between Universidad Nacional Autónoma de Nicaragua, León (UNAN-León) and the University of North Carolina at Chapel Hill (UNC), existing collaborative research for trainee projects, and strong bilateral institutional support. The program’s objectives include: 1) Provide long-term, pre-doctoral training in infectious disease epidemiology at UNC to two young investigators from UNAN-León. These graduates will contribute to the core research faculty at UNAN-León to address pressing local research agendas; 2) Create a sustainable supply of well-trained biomedical scientists in the region by establishing an accredited PhD program in Biomedical Sciences at UNAN- León; we will enroll five pre-doctoral candidates in the initial cohort. This program builds upon a successful Master’s program of Microbiology in place at UNAN-León and fills a huge need in Nicaragua for rigorous PhD- level biomedical research training. We further support five of these pre-doctoral trainees for one-month long laboratory trainings at UNC. 3) Foster professional growth and research skills development among 140 trainees of all levels, including local faculty, to ensure academic and research success. Robust short-term trainings in professional and research skills needed to become an independent investigator and successful academician are provided to both trainees and local faculty to ensure that the program’s impacts extend more broadly. This program will result in a multidisciplinary research team at UNAN-Leon to confront the emerging and endemic viral diseases that affect public health both regionally and globally. Our approach is made feasible by leveraging an existing successful Master’s program at UNAN-León and by providing trainees the opportunity to partner with mentors at both UNC and UNAN-León on a growing array of collaborative research projects.