Core B - Biospecimens

爱荷华州神经内分泌肿瘤(NET)孢子生物样本核心提供了一个协调、集中和 用于从我们爱荷华州的患者那里采购、处理和注释生物标本的专用核心 神经内分泌肿瘤登记处和SEER残留组织储存库。的主要目标是 Biopecimens的核心是获取各种神经内分泌肿瘤患者的生物标本。 这些标本将包括来自签署爱荷华网的患者的新鲜或快速冷冻的标本。 获得注册同意书以及未识别的福尔马林固定石蜡包埋(FFPE)标本 通过监测流行病学和最终结果(SEER)残留组织储存库(RTR)。全 样本将被跟踪并储存在优化其对分子研究的效用的条件下，以确保 爱荷华州网状孢子调查人员已经接触到了大量种类繁多的网状肿瘤， 和生殖系标本。 所有的生物标本将被收集、跟踪并分发给孢子研究人员，在建立了 霍尔顿综合癌症中心(HCCC)爱荷华州肿瘤采购中心(TPC)的方案 还有爱荷华州的SEER。所有标本都在严格的质量控制下收集和加工，并进行跟踪和 分发给孢子研究人员或为未来的孢子研究项目存入银行。核心跟踪 获取、分配和在这些标本上获得的结果，允许与临床和其他 在研究项目中收集的数据。核心受益于HCCC的专业知识，但不会重复 它的服务。核心支持每个完整的和发展的项目。已经有了广泛的 这些生物样本的利用和由此产生的临床和表型数据已经在我们的爱荷华州网络数据库中。 我们将继续收集新的患者样本以及保存FFPE样本，并将继续 与研究人员合作，利用这一日益宝贵的资源来治疗这些孤儿肿瘤。 Biopecimens Core的具体目标是：1)收集、处理、储存和分发多余的外科手术 已签署同意的患者和家属的样本和/或血液/口腔拭子 参与爱荷华州网络注册；2)获取、处理和分发未识别的神经内分泌肿瘤 通过爱荷华州虚拟肿瘤储存库和SEER残留组织储存库获得的FFPE标本； 3)根据北美神经内分泌对所有肿瘤标本提供准确的诊断和分级 肿瘤学会(NANETS)指南；4)与生物统计和生物信息学核心合作维护数据 从爱荷华州网络注册处和SEER储存库获得的生物样本将进一步合作 研究导致改善NETS患者的长期结果。

The Iowa Neuroendocrine Tumor (NET) SPORE Biospecimens Core provides a coordinated, centralized, and dedicated core for the procurement, processing and annotation of biospecimens from patients in our Iowa Neuroendocrine Tumor Registry and also from SEER Residual Tissue Repositories. The primary goal of the Biospecimens Core is to procure a variety of biologic specimens on patients with neuroendocrine tumors. These specimens will include fresh or rapidly frozen specimens from patients who have signed the Iowa NET Registry consent as well as de-identified, formalin-fixed paraffin-embedded (FFPE) specimens obtained through the Surveillance Epidemiology and End Results (SEER) residual tissue repository (RTR). All specimens will be tracked and stored under conditions that optimize their utility for molecular studies, assuring the Iowa NET SPORE investigators have access to a large number of a wide variety of NET tumor, normal, and germline specimens. All biospecimens will be collected, tracked and distributed to SPORE researchers following the established protocols of the Iowa Tumor Procurement Core (TPC) in the Holden Comprehensive Cancer Center (HCCC) and the Iowa SEER. All specimens are collected and processed under tight quality control, tracked and distributed to SPORE researchers or banked for future SPORE research projects. The Core tracks the acquisition, distribution, and results obtained on these specimens, allowing integration with clinical and other data collected in research projects. The Core benefits from the expertise in the HCCC, but does not duplicate its services. The Core supports each of the full and developmental projects. There has been extensive utilization of these biospecimens with resulting clinical and phenotypic data already in our Iowa NET Database. We will continue to accrue new patient samples as well as repository FFPE specimens and will continually work with investigators to utilize this increasingly valuable resource for these orphan tumors. Specific Aims of the Biospecimens Core are: 1) Collect, process, bank and distribute excess surgical specimens and/or blood/buccal swabs from patients and family members who have signed consent to participate in the Iowa NET Registry; 2) Acquire, process, and distribute de-identified neuroendocrine tumor FFPE specimens obtained through the Iowa Virtual Tumor Repository and SEER Residual Tissue Repository; 3) Provide accurate diagnosis and grade on all tumor specimens according to North American Neuroendocrine Tumor Society (NANETS) guidelines; 4) Work with the Biostatistics and Bioinformatics Core to maintain data obtained from Iowa NET Registry biospecimens and SEER Repository biospecimens to further collaborative research leading to improved long term outcomes for patients with NETs.