Integrative Biostatistics and Informatics Core

综合生物统计和信息学核心(IBIC)将提供实验设计、数据方面的专业知识 管理和分析由MNORC进行的临床前、临床和转化性研究 研究基地的调查人员。CORE将专注于在数据库设计方面提供帮助，使其能够接受 多种数据类型，包括源自多种组学技术的分子表型。后者将 需要适当的数据架构和工具来集成和可视化数据。IBIC将确保所有临床上 相关数据库将符合《健康保险可携带性和问责法》(HIPAA)。IBIC将 继续支持密歇根临床与健康研究所的研究基地调查人员 (MICHR)、计算医学和生物信息学系(DCMB)和BRCF生物信息学 核心，以提供额外的生物统计和信息学服务。核心还将继续开发新的 相关数据库的数据挖掘工具以及各种软件使用方面的协助和培训， 用于分析基因组、转录组、代谢组和蛋白质组数据的云和服务工具。 最后，IBIC人员将与其他核心和体重管理计划合作开发 适当的数据格式和数据库结构，以集成临床、分子、神经行为和其他 将表型数据转换为便于生物统计和信息学方法分析的格式。

The Integrative Biostatistics and Informatics Core (IBIC) will provide expertise in experimental design, data management and analysis for preclinical, clinical and translational research studies conducted by MNORC Research Base investigators. Core will focus on providing assistance in data base design that can accept multiple data types, including molecular phenotypes derived from multiple ‘omics technologies. The latter will require proper data architecture and tools to integrate and visualize data. The IBIC will assure that all clinically relevant databases will be Health Insurance Portability and Accountability Act (HIPAA) compliant. The IBIC will continue support for Research Base investigators with the Michigan Institute for Clinical and Health Research (MICHR), the Department of Computational Medicine and Bioinformatics (DCMB) and the BRCF Bioinformatics Core, to provide additional biostatistics and informatics services. The Core will also continue to develop new tools for data mining of relevant databases as well as assistance and training in the use of various software, Cloud and service tools for analysis of genomic, transcriptomic, metabolomic and proteomic data. Finally, IBIC personnel will collaborate with other Cores and the Weight Management Program to develop appropriate data formats and database constructs to integrate clinical, molecular, neurobehavioral and other phenotypic data into formats that ease analysis by biostatistical and informatics methodologies.