FASEB SRC on Lysophospholipid and Related Mediators: From Bench to Clinic

摘要 FASEB溶血磷脂及相关介质夏季研究会议-从实验室到临床 将于2019年7月28日至8月2日在葡萄牙里斯本的万豪酒店举行。本次会议将讨论 目前的研究和新兴概念主要涉及溶血磷脂鞘氨醇-1-磷酸 (S1P)和溶血磷脂酸（LPA）及其在健康和疾病中的作用。S1 P和LPA是脂质信号传导 分别激活5和6 G蛋白偶联受体并结合细胞内靶蛋白的激动剂 来调节细胞生物学。这些生物相互作用控制着与再生医学相关的许多功能。 这些脂质在癌症、囊性纤维化、免疫疾病和其他生理病理学疾病中是重要的。 疾病状态。调节溶血磷脂代谢的受体和细胞内酶都已被发现。 显示作为潜在的治疗靶点来诊断、预防或治疗疾病。会议将 强调将这项工作转化为临床实践，并强调正在取得的研究进展， 许多新的研究人员在这个领域的快速步伐。会议提供了一个独特的论坛， 该领域的科学家们在一个非正式和轻松的会议上讨论他们的最新研究成果， 气氛会议的目的是1）提供科学家和学员之间的知识交流， 溶血磷脂研究; 2）鼓励和促进早期职业和新的职业之间的积极讨论 通过互动式职业讲习班，为研究人员和知名科学家提供机会; 3） 网络/协作，职业发展/培训和就业机会;以及4）提供平台， 促进妇女和代表性不足的少数群体的参与。会议将允许不同的早期 职业生涯和既定的研究人员交流最新的研究成果，并促进未来 这些相互作用与开发溶血磷脂发挥主要作用的疾病的疗法一致。 在葡萄牙的会议地点将促进欧洲科学家与其他国家的最大参与 国外和美国同行促进富有成效的互动，重点是翻译的影响， 溶血磷脂

Abstract The FASEB Summer Research Conference on Lysophospholipid and Related Mediators-From Bench to Clinic will be held July 28- August 2, 2019 at the Marriott Hotel in Lisbon, Portugal. This conference will address current research and emerging concepts related mainly to the lysophospholipids sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) and their roles in health and disease. S1P and LPA are lipid signaling agonists that activate 5 and 6 G protein-coupled receptors, respectively and bind to intracellular target proteins to regulate cell biology. These biological interactions control many functions related to regenerative medicine. These lipids are important in cancer, cystic fibrosis, immunologic disorders and other physiopathological disease states. Both receptors and intracellular enzymes regulating lysophospholipid metabolism have been shown to function as potential therapeutic targets to diagnose, prevent or treat disease. The conference will emphasize the translation of this work into clinical practice and highlight the research advances being made at a rapid pace by many new investigators in this field. The meeting provides a unique forum for multidisciplinary scientists within the field to meet and discuss their latest research findings in an informal and relaxed atmosphere. Conference aims are to 1) provide intellectual exchange between scientists and trainees in lysophospholipid research; 2) encourage and facilitate the active discussion between early career and new investigators and established scientists via interactive career workshops; 3) provide opportunities for networking/collaboration, career development/training, and job opportunities; and 4) provide a platform to promote the participation of women and underrepresented minorities. The conference will allow diverse early career and established investigators to communicate late breaking research results and promote future interactions aligned with developing therapies for diseases where lysophospholipids play a predominant role. The conference site in Portugal will facilitate maximum participation of European scientists with other countries abroad and US counterparts to promote productive interactions focusing on the translational implications of lysophospholipids.