2019 Multi-Drug Efflux Systems GRC/GRS

项目摘要 发现和临床使用小分子疗法治疗传染病的现代时代是 受到迅速传播的抗药性的威胁。耐药性影响到所有主要的感染性群体 疾病，但在腹泻和肺炎等破坏性感染的病原体中尤其令人不安 呼吸道疾病、疟疾和结核病。基础、翻译和药物之间的协同努力 迫切需要发现研究人员来防止耐药性的进一步传播，并开发有效的 预测和对抗当前和未来耐药病原体的方法。本建议书要求 部分支持戈登研究会议(GRC)和戈登研究研讨会(GRS) 多药外流系统将于2019年4月27日至5月3日在意大利巴尔加举行。这次会议将填补以下方面的重大空白 处理关键问题和新办法，以实现有效扭转持续存在的目标 世界范围内的多药耐药性以及最佳疗效和降低毒性的治疗药物的开发。 本次会议和研讨会的目标是提供一个激励和合作的环境 研究人员公开讨论未发表的工作，突破科学的界限，促进科学 青年研究人员、该领域的领导者与学术界和 制药/生物技术行业。一个主要目标是将在不同领域拥有专业知识的研究人员聚集在一起。 传统上在分享进展和参与挑战讨论方面互动有限的学科 以及这一领域的机会。研究多药耐药泵的研究人员参与了 微生物和研究哺乳动物外排泵的人旨在引入技术进步 以及每个领域的变革性方法。这一全球资源中心的目标将由国际上的 公认的主旨演讲者，八次科学会议，邀请了30多名演讲者和其他 讨论领袖，以及促进与会者之间富有成效的互动的独特形式和环境 职业生涯的所有阶段。每节课的演讲者将介绍前沿的、未发表的数据和创新的想法 对于以多药外排泵为靶点逆转耐药性至关重要的问题。这个 GRC科学会议和海报会议的互动性以及来自不同领域的研究人员的参与 研究部门是研究生和博士后研究员扩大他们的科学研究的最佳论坛 广度，与该领域的领导者互动，建立未来的协作关系并考虑各种 职业道路。来自受训者和代表性不足的少数族裔提交的摘要将以口头形式为目标 每节课的演讲。通过在主会议之前参加GRS，受训人员将 有更多机会进行口头和海报演示，并在 培育环境。2019年关于多药外排系统的GRC和GRS将进一步刺激尖端 多药耐药这一重要生物医学问题的基础和翻译研究。

Project Summary The modern era of discovery and clinical use of small molecule therapeutics to treat infectious diseases is threatened by rapidly spreading drug resistance. Drug resistance affects all major groups of infectious diseases but is particularly troubling among causative agents of such devastating infections as diarrheal and respiratory diseases, malaria and tuberculosis. Concerted efforts among basic, translational and drug discovery researchers are urgently needed to prevent further spread of resistance and to develop effective approaches to anticipate and to counter present and future drug resistant pathogens. This proposal requests partial support for the Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) on Multidrug Efflux Systems to be held in Barga, Italy, April 27-May 3, 2019. This conference will fill a major gap in addressing critical issues and novel approaches to achieve the goals of effective reversal of persistent multidrug resistance worldwide and the development of therapeutics with optimal efficacy and reduced toxicity. The goal of this conference and seminar is to provide a stimulating and collaborative environment for researchers to openly discuss unpublished work, push the boundaries of science, and foster scientific interactions between young investigators, leaders in the field, and colleagues working in academia and the pharmaceutical/biotechnology industry. A major goal is to bring together researchers with expertise in diverse disciplines who traditionally have limited interaction to share progress and engage in discussion of challenges and opportunities in the field. The participation of researchers studying multidrug resistance pumps in microorganisms and those studying mammalian efflux pumps is designed to introduce technological advances and transformative approaches to each field. The goals of this GRC will be accomplished by the internationally recognized keynote speakers, the eight scientific sessions with over 30 invited speakers and additional discussion leaders, and the unique format and setting that facilitates fruitful interactions between participants at all career stages. Speakers in each session will present cutting-edge, unpublished data and innovative ideas on issues that are critical to the success of targeting multidrug efflux pumps for the reversal of resistance. The interactive nature of the GRC scientific and poster sessions and the participation of researchers from diverse research sectors is an optimal forum for graduate students and postdoctoral fellows to expand their scientific breadth, interact with leaders in the field, establish future collaborative relationships and consider various career paths. Submitted abstracts from trainees and underrepresented minorities will be targeted for oral presentations in each session. Through participation in the GRS prior to the main conference, trainees will have additional opportunities for oral and poster presentations and to develop relationships with their peers in a nurturing environment. The 2019 GRC and GRS on Multidrug Efflux Systems will further stimulate cutting-edge basic and translational research on the important biomedical problem of multidrug resistance.