Evaluating New Nicotine Standards for Cigarettes - Core C

核心C-生物统计和数据管理 生物统计和数据管理核心提供广泛的统计服务，以支持 三个项目。核心将提供关于实验设计的建议-例如终点的选择和 可能的分层、考虑和计算样本量和统计能力。核心是 负责在一个高度重视数据的安全中央数据库中进行所有方面的数据管理 诚信和品质。核心将形成计划并以一致的格式执行专家统计分析 在项目之间使用实践中最先进的技术。核心还将促进数据共享 该计划中的项目之间以及遵循NIH指导方针的一般科学界之间的合作。 核心的工作人员包括一名担任礼宾管理员(数据管理员)的生物统计员和三名高度 与项目调查人员有日常工作关系的有经验的生物统计师。《核心》 生物统计学家一直是拟议方案发展的一个组成部分，并参与了 随着这组调查人员的最后4-5年的这一目前的CENIC拨款。 生物统计和数据管理核心的主要目标是促进科学和 通过全面参与中心的活动，确保中心的运作。核心统计学家具有广泛的长期经验 擅长实验设计、数据收集、数据存储、数据分析和结果解释 根据需要纳入新的和复杂的统计程序。通过提供专业研究 为每个项目的数据分析活动提供方法和后勤支持，该核心将增强数据 口译和科学生产力。

Core C – Biostatistics and Data Management The Biostatistics and Data Management Core provides a broad array of statistical services in support of the three Projects. The Core will provide advice on experimental design - such as selection of end points and possible stratification, consideration and calculation of sample size and statistical power. The Core is responsible for all aspects of data management in a secure central database with strong emphasis of data integrity and quality. The Core will form plans and perform expert statistical analyses in a format consistent between Projects using techniques that are state of the art in practice. The Core will also facilitate data sharing between projects in the Program as well as the general scientific community following NIH guidelines. The Core is staffed by one biostatistician serving as Protocol Manager (Data Manager) and three highly experienced biostatisticians who have daily working relationships with the Project investigators. The Core biostatisticians have been an integral part in the development of the proposed Program and have participated with this group of investigators the last 4-5 years of this current CENIC grant. The primary objective of the Biostatistics and Data Management Core is to contribute to the science and operation of the center by participating fully in its activities. Core Statisticians have broad long-standing expertise in experimental design, data collection, data storage, data analysis, and interpretation of results incorporating novel and complex statistical procedures as needed. By providing expertise research methodology and logistical support to data analytic activities with each Project, this Core will enhance data interpretation and scientific productivity.