Molecular Pathogenesis of Infectious Diseases

这份申请是我们跨学科博士前培训计划的第三次竞争性更新。 科罗拉多·安舒茨大学传染病(MPID)分子发病机制研究 医学院。在六个系拥有分支机构的26名教职员工为我们的实习生提供了 研究允许革兰氏阳性和阴性的RNA和DNA病毒的分子机制 细菌、结核分枝杆菌和原生动物寄生虫引起的发病率和死亡率 世界各地的人类。MPID学员可以获得基本的、基因组的、计算的、翻译的和 系统生物学研究。我们的培训教师在以下方面证明了创新研究的效率 传染病，从他们的实验室平均每年收到75万美元的事实可以看出 直接成本。学生在完成培训后被挑选出来参加这项培训计划 他们的必修课程，通过了初步和全面的考试，并开始了他们的 论文研究。自2002年首次获奖以来，MPID项目已资助了49名学生，占 他们是代表不足的少数民族。在过去的5年里，90%的学生加入了MPID 培训计划获得了州外机构的本科学位。的实验室 培训人员从每年28名研究生扩大到平均每年出版3.4篇论文 从上一个资助时期(2007-2013)的学生增加到每年约35人，平均为4.6 最近4年每个学生发表的论文数量。除了完成课程作业和进行他们的 指导研究项目，MPID学生参与并在研讨会、期刊中担任领导角色 俱乐部、进行中的研究会议以及MPID小型研讨会和研讨会。这一全面的 培训使我们的学生做好准备，以确定重要的研究问题，设计良好控制 结合尖端方法的实验，批判性地评估和展示其结果，以及 理解并将伦理原则应用于他们的研究。研究的广度，说教，和 领导力机会为平庸的学生在学术界、工业界和 政府。MPID毕业生在工业领域担任高级职位(67%)，在学术领域担任教职 机构(15%)或政府(6%)。有20%的受训人员隶属于 MPID培训计划目前正在一流的机构中攻读博士后奖学金，以及 8%继续接受医学教育。我们的学员已经获得了NIH F31、F32和R01的资金。vt.给出 培养学生在广泛的传染病领域的重要性，成功的记录 MPID培训计划，以及我们T32培训人员和培训教师数量的增加 由于自2002年获奖以来一直受到支持，我们请求支持增加一个名额。这表示一个 在过去10年期间提供经费的职位增加1至4个，每年总共增加5个职位。

This application is for the third competing renewal of our interdisciplinary pre-doctoral training program on The Molecular Pathogenesis of Infectious Diseases (MPID) at the University of Colorado Anschutz Medical Campus. Twenty-six faculty with affiliations in six departments offer our trainees opportunities to investigate molecular mechanisms that allow RNA and DNA viruses, Gram-positive and -negative bacteria, Mycobacterium tuberculosis, and protozoan parasites to cause morbidity and mortality in humans worldwide. MPID trainees have access to basic, genomic, computational, translational and systems biology research. Our training faculty have demonstrated productivity for innovative research in infectious diseases, illustrated by the fact that their labs receive an average of $750,000 per year in direct costs. Students are selected for appointment to this training program after they have completed their required coursework, passed their preliminary and comprehensive examinations, and begun their dissertation research. Since the initial award in 2002, the MPID program has funded 49 students, 8% of whom were underrepresented minorities. In the last 5 years, 90% of students affiliated with the MPID Training Program obtained undergraduate degrees from out-of-state institutions. The laboratories of training faculty expanded from 28 graduate students per year with an average of 3.4 publications per student in the previous funding period (2007-2013) to about 35 per year with an average of 4.6 publications per student in the last 4 years. In addition to completing coursework and conducting their mentored research projects, MPID students participate in and assume lead roles in seminars, journal clubs, research-in-progress meetings, and MPID mini-symposia and workshops. This comprehensive training prepares our students to identify important research questions, design well-controlled experiments incorporating cutting-edge approaches, critically evaluate and present their results, and understand and apply principles of ethics to their research. The breadth of the research, didactic, and leadership opportunities prepares MPID students for successful careers in academia, industry, and government. MPID graduates hold senior positions in industry (67%), faculty positions at academic institutions (15%), or government (6%). Twenty percent of trainees who have been affiliated with the MPID Training Program are currently pursuing postdoctoral fellowships in high ranked institutions, and 8% continue their medical education. Our trainees have secured NIH F31, F32, and R01 funding. Given the importance of training students in the broad field of infectious diseases, the successful record of the MPID Training Program, and the increased number of trainees and training faculty that our T32 has supported since it was awarded in 2002, we request support for an additional slot. This represents an increase of one to the four positions funded during the last 10 years, for five total slots per year.