2019 Excitatory Synapses and Brain Function Gordon Research Conference and Seminar

总结 该提案要求R13支持长期的，参与人数众多的，广受欢迎的戈登研究 兴奋性突触和脑功能会议（GRC）于2019年6月9日至14日在新英格兰大学举行， 比德福德ME. GRC之前将举行戈登研究研讨会（GRS），针对研究生 学生和博士后研究员于2019年6月8日，9日在同一地点。突触是我们大脑 了解大脑的功能和行为。在中枢神经系统中，兴奋性突触代表了 通过局部电路和大脑区域之间的通信进行信息处理的主要手段， 用于调节感觉处理、运动控制、认知和行为。重要的是，突触作为 许多常用处方药的作用部位和突触功能障碍导致许多 神经和精神疾病。包括精神分裂症，自闭症，抑郁症，药物成瘾， 帕金森氏病，阿尔茨海默氏病，创伤性脑损伤，中风和癫痫。在某些情况下，突触 功能障碍在疾病中是因果关系，而在其他情况下，它代表一种或多种疾病的下游后遗症。 潜在的分子缺陷因此，针对这些疾病的治疗策略靶向于修饰、修复或治疗这些疾病。 维持突触功能因此，对突触发育，结构， 健康和患病大脑中的分子组织、信号功能和可塑性对于 减轻人类神经系统疾病的负担，预测和改善心理健康。这 会议的独特之处在于它专注于兴奋性突触，大脑中的主要突触类型， 多学科小组的参与者，包括结构生物学家，分子和发育生物学家，细胞 生物学家、生物化学家、生物药理学家、神经生理学家和系统神经科学家。裁谈会 旨在将兴奋性突触功能的基本见解与突触功能的损伤联系起来， 神经系统疾病中出现的适应不良，以及导致药物成瘾的适应不良可塑性。目标 会议的目的是确定和强调对突触功能和功能障碍的基本新见解 从主题的角度。该计划的目的也是为了突出尖端的方法， 在健全的基本生物学框架内激发新的概念、方法和技术 神经科学这次会议将使世界各地的专家科学家聚集在一个有利的环境， 讨论和交换意见。这次会议上的思想交流是推动 领域我们预计2019年兴奋性突触和大脑功能的GRC将塑造未来的科学方向 并为NINDS的使命以及其他NIH研究所（如NIMH，NIDA和 NIA

Summary This proposal requests R13 support for a longstanding, well-attended, and well-received Gordon Research Conference (GRC) on Excitatory Synapses and Brain Function on June 9-14, 2019 at University of New England, Biddeford ME. The GRC will be preceded by a Gordon Research Seminar (GRS) targeted towards graduate students and postdoctoral fellows on June 8, 9 2019 at the same location. The synapse is central to our understanding of brain function and behavior. In the central nervous system, excitatory synapses represent the primary means of information processing by local circuits and communication between brain regions and thus serve to mediate sensory processing, motor control, cognition and behavior. Importantly, synapses serve as the site of action for many commonly prescribed medications and synaptic dysfunction contributes to many neurological and psychiatric disorders. These include schizophrenia, autism, depression, drug addiction, Parkinson's disease, Alzheimer's disease, traumatic brain injury, stroke and epilepsy. In some cases, synaptic dysfunction is causal in disease, whereas in other cases it represents the downstream sequelae of one or more underlying molecular defects. Thus, therapeutic strategies for these diseases are targeted to modify, repair or maintain synaptic function. Therefore, a fundamental understanding of synapse development, structure, molecular organization, signaling function, and plasticity in both the healthy and diseased brain is essential to lessening the burden of human neurological disease and predicting and improving mental health. This conference is unique in its focus on excitatory synapses, the major synapse type in the brain, and in its multidisciplinary group of participants including structural biologists, molecular and developmental biologists, cell biologists, biochemists, biophysicists, neurophysiologists and systems neuroscientists. The conference is intended to relate fundamental insights in excitatory synaptic function to the impairments in synaptic function that occur in neurological disease, as well as the maladaptive plasticity that contributes to drug addiction. The goal of the conference is to identify and highlight fundamental new insights into synaptic function and dysfunction from a thematic approach. The program has been designed to also highlight cutting edge approaches and to stimulate new concepts, methods and technologies within a sound biological framework of fundamental neuroscience. The conference will bring together expert scientists worldwide in an environment that is conducive to discussion and exchange of ideas. The exchange of ideas at this conference has been a driving force for the field. We expect the 2019 GRC on Excitatory Synapses and Brain Function will shape future scientific directions and provide critical support for the mission of NINDS as well as other NIH institutes such as NIMH, NIDA and NIA.