Sequencing and Genotyping in Diverse Populations: Who Wants What Back (and When)?

项目摘要 北海岸精准医学会议是一个全国性的年度中型会议系列， 克利夫兰，俄亥俄州。该系列会议旨在作为继续教育和交流的场所， 与快速发展和高度跨学科的景观相关的科学思想，即精准医学 research.每次会议的主题都与国家对话和研究议程相吻合， 专注于精准医疗的国家研究计划。2018年会议是一个研讨会，将重点关注 关于临床和研究环境中基因组结果返还的相关问题， 人口。会议将以传统形式组织，邀请各国政府和民间社会的代表发言。 专家的主题范围从问题返回研究成果，以文化多样性的参与者和家庭 成员，在临床测序证据中纳入不同的患者和参与者人群- 生成研究（CSER）联盟和Trans-Omics for Precision Medicine（TOPMed）计划， 药物遗传学指导的剂量和人种/种族，用于返回结果的策略等。2019年及 除了会议主题正在考虑从以前的研讨会与会者和趋势的精度 医学研究。奇数年会议包括一个讲习班部分， 涵盖了从电子健康记录中提取的结果和暴露变量。未来研讨会的主题是 考虑包括多组学的整合，不同人群的药物反应，药物基因组学 临床实施、癌症精准医疗、数据共享和知情同意，以及应用程序的使用 用于招募、诊断、随访和治疗。本次系列会议的第二个主要目标是 促进生物医学劳动力的多样性。众所周知，从培训到正式教授的管道 妇女在生物医学研究中的作用是泄漏的，而代表性不足的少数民族的管道实际上是 根本不存在从国家和地方来源，我们审查妇女和代表性不足的少数民族， 每一个受邀演讲者的机会，从而提供宝贵的职业货币和网络机会。我们 还将鼓励妇女和代表性不足的少数民族，特别是在受训人员一级，参加和 参加这一系列会议，以激发人们对从事精准医学研究的兴趣。总体而言， 北海岸精准医学系列会议是对全国会议的宝贵补充 景观，并以其独特的位置和低成本的参与者，将作为一个重要的教育， 随着精准医学研究的加速，这是一个机遇。

PROJECT SUMMARY The North Coast Conference on Precision Medicine is a national annual mid-sized conference series held in Cleveland, Ohio. The conference series aims to serve as a venue for the continuing education and exchange of scientific ideas related to the rapidly evolving and highly interdisciplinary landscape that is precision medicine research. The topics for each conference coincide with the national conversation and research agenda set by national research programs focused on precision medicine. The 2018 conference is a symposium that will focus on issues related to return of genomic results both in clinical and research settings with an emphasis on diverse populations. The conference will be organized as a traditional format with invited speakers from among national experts for topics ranging from issues returning research results to culturally diverse participants and family members, inclusion of diverse patient and participant populations in the Clinical Sequencing Evidence- Generating Research (CSER) consortium and the Trans-Omics for Precision Medicine (TOPMed) Program, pharmacogenomics-guided dosing and race/ethnicity, strategies used to return results, among others. 2019 and beyond conference topics are being considered from previous symposia attendees and trends in precision medicine research. Odd-numbered year conferences include a workshop component that has previously covered outcome and exposure variable extraction from electronic health records. Future workshop topics being considered include integration of multiple ‘omics, drug response in different populations, pharmacogenomics clinical implementation, precision medicine in cancer, data sharing and informed consent, and the use of apps for recruitment, diagnosis, follow-up, and treatment. Our second major objective of this conference series is the promotion of diversity in the biomedical workforce. It is well-known that the pipeline from training to full professor for women in biomedical research is leaky whereas the pipeline for under-represented minorities is practically non-existent. Drawing from national and local sources, we vet women and under-represented minorities for every invited speaker opportunity, thereby providing valuable career currency and networking opportunities. We will also encourage women and under-represented minorities, particularly at the trainee level, to attend and participate in this conference series to spur interest in pursuing precision medicine research as a career. Overall, the North Coast Conference on Precision Medicine series is a valuable addition to the national conference landscape, and with its unique location and low cost to participants, will serve as an important educational opportunity as precision medicine research accelerates in earnest.