Molecular Regulation of Cell Development and Differentiation Phase III COBRE

总体项目摘要 摘要 要求提供资金，以更新生物医学研究卓越中心（COBRE）， 堪萨斯大学医学中心（KUMC）作为第三阶段，五年奖。这个眼镜蛇 研究重点是细胞发育和分化的调节， 为许多发育异常和疾病提供了新的治疗见解。 在最初的10年任期内，我们将培训15名初级调查员， 他们正在成为成功的独立研究者。这其中的一个重要特征 应用是维护3个科学核心，为所有 中心教师以及KUMC作为一个整体。连同行政核心A， 在小鼠和大鼠中有支持转基因的核心（核心B），分子谱（下 代测序，微阵列和生物信息学，核心C），和高分辨率 成像（共聚焦和电子显微镜，核心D）。第二个主要组成部分是 申请是在发育生物学试点项目计划的运作， 代表了在第一阶段和第二阶段启动的试点计划的自然延伸， 成功的记录优秀的科学人才组合，实力雄厚 研究环境，以及对科学核心和 试点项目计划确保该COBRE将继续促进 专题，多学科的研究工作，提高KUMC研究人员的能力， 争取校外支持

OVERALL PROJECT SUMMARY ABSTRACT Funds are requested to renew a Center of Biomedical Research Excellence (COBRE) at the University of Kansas Medical Center (KUMC) as a Phase III, five year award. This COBRE has a research focus on the regulation of cell development and differentiation, which may provide new, therapeutic insights into a host of developmental abnormalities and diseases. During the initial 10 year term, we will have trained 15 Beginning Investigators and most of them are becoming successful, independent researchers. An important feature of this application is the maintenance of 3 scientific Cores that provide research support to all of the Center faculty as well as to KUMC as a whole. Together with Administrative Core A, there are Cores supporting transgenesis in mice and rats (Core B), molecular profiling (next generation sequencing, microarray, and bioinformatics, Core C), and high resolution imaging (confocal and electron microscopy, Core D). The second major component of this application is the operation of a Pilot Projects Program in developmental biology, which represents a natural extension of a pilot program initiated in Phase I and II that has a proven, successful track record. The outstanding combination of scientific talent, strong research environment, and substantial institutional commitment to the scientific Cores and Pilot Projects Program ensure that this COBRE will continue to foster the development of a thematic, multidisciplinary research effort and enhance the ability of KUMC researchers to compete for extramural support.