Mentoring and research in translational neuroscience of integrative medicine

摘要/摘要 以患者为中心的补充和综合医学(CIM)转化研究已成为当务之急 鉴于公众对CIM方法的使用越来越感兴趣，开发一条合格调查人员的渠道 以及它们在治疗和预防重大疾病方面的有效性的证据基础有限。下一个 新一代CIM研究人员将受益于职业生涯中期经验丰富的临床经验的专注指导 调查人员。加州大学洛杉矶分校精神病学教授、医学博士、医学硕士海伦·拉夫雷茨基被授予塞梅尔学者 是一名临床研究员，致力于以患者为中心的综合心理健康研究 医学和心理健康。拉夫雷茨基博士在研究、出版、教学和 辅导。她指导的K23(2001-2007)和第一批K-24(2010-2015)职业发展补助金 NIMH，以及随后从NIMH和NCCIH获得的几项R01研究拨款，专注于开发 老年情绪和认知的联合互补治疗和预防方法 精神错乱。Lavretsky博士指导初级教员、研究生和博士后学生、住院医师和 医科学生。在第一届K24奖项期间指导的22名学员中，有11名(50%)现在拥有自己的NIH 其他人仍在从事临床研究和培训。 这项拟议的K24职业生涯中期研究人员奖将在以患者为导向的研究中提供保护时间和 帮助扩展拉夫雷茨基博士在心理-身体翻译神经科学方面的研究和指导计划 干预措施，并向初级CIM调查人员提供指导。这项计划的主要目标是：1. 测试身心干预的健康益处；2：应用创新技术测试 中西医结合疗法的神经再生和基因组作用机制；以及3：发展 CIM未来研究人员的管道。拉夫雷茨基博士正在开发一门课程，用于培训青少年 加州大学洛杉矶分校CTSI项目整合医学转化科学的研究人员，以及 综合医学阳性神经科学研究生学位课程，并计划向 NCCIH在未来两年申请T-32 NRSA机构研究培训补助金。这些培训补助金将 允许在加州大学洛杉矶分校开发一个以CIM为目标的研究培训计划。与现有的 加州大学洛杉矶分校CTSI和综合医学合作中心的资源和声誉，这将 吸引越来越多最合格、最有前途的未来CIM研究人员。拟议的研究 额外的培训将建立在以前研究结果的基础上，特别是NCCIH资助的R-01 太极拳研究。K-24奖项建议的项目将扩大到多模式磁共振成像的试点研究，以聚焦 1)MRS/DTI/fMRI的初步研究，以及2)太极反应的基因表达预测指标。这个K24 应用程序旨在提供指导和研究环境，以发展格外强大和 不同的CIM研究人员群体，他们将在未来的综合医学研究中发挥主导作用。

Abstract/Summary Patient-oriented translational research in complementary and integrative medicine (CIM) has an urgent need for developing a pipeline of qualified investigators given increased public interest in the use of CIM approaches and the limited evidence base for their efficacy for treatment and prevention of major disorders. The next generation of CIM researchers will benefit from the dedicated mentorship of experienced midcareer clinical investigators. Helen Lavretsky, M.D., M.S., a Professor of Psychiatry at UCLA, was named the Semel Scholar in Integrative Mental Health, and is a clinical investigator dedicated to patient-oriented research in integrative medicine and mental health. Dr. Lavretsky has a strong record of research, publication, teaching and mentoring. Her mentored K23 (2001-2007), and the first K-24 (2010-2015) career development grants from the NIMH, and several subsequent R01 research grants from the NIMH and NCCIH focused on developing combination and complementary treatment and prevention approaches for late-life mood and cognitive disorders. Dr. Lavretsky mentors junior faculty, graduate and post-doctoral students, resident physician, and medical students. Of the 22 trainees mentored during the first K24 award, 11 (50%) now have their own NIH grants or other career grants, and others are still engaged in clinical research and training. This proposed K24 Midcareer Investigator Award in Patient-Oriented Research will provide protected time and help expand Dr. Lavretsky's research and mentoring program in translational neuroscience of mind-body interventions, and to extend mentorship to junior CIM investigators. The main aims of this program will be: 1: Testing the health benefits of mind-body interventions; 2: Applying innovative technologies to test the neuroplastic and genomic mechanisms of action of integrative medicine therapies; and 3: Developing the pipeline of future researchers of CIM. Dr. Lavretsky is developing a curriculum for training of junior investigators in translational science of integrative medicine for the UCLA CTSI program, as well as a Graduate Degree course in positive neuroscience of integrative medicine, and plans to submit an application to NCCIH for a T-32 NRSA Institutional Research Training Grant in the next two years. These training grants will allow the development of a CIM-targeted research training program at the UCLA. Combined with existing resources and reputation of the UCLA CTSI and Collaborative Centers for Integrative Medicine, this would attract an increasing pool of the most qualified and promising future CIM researchers. The proposed research and additional training will build upon findings from previous research; especially the NCCIH-funded R-01 study of Tai Chi. The K-24 award proposed project will expand to the pilot studies of multimodal MRI to focus on 1) a pilot study of MRS/ DTI/ fMRI, and 2) gene expression predictors of response to Tai Chi. This K24 application aims to provide mentoring and a research environment to develop an exceptionally strong and diverse group of CIM researchers who will play leading roles in the future of integrative medicine research.